Production of Lactobacilli Proteinases for the Manufacture of Bioactive Peptides: Part I-Upstream Processes
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This chapter focuses on the metabolism of genus Lactobacillus, with emphasis on the proteolytic potential of the well-known species in order to highlight their potential use in the production of bioactive peptides. Fermentation activities for most of the literature references used in this chapter were conducted in batch mode but the focus of the studies was not on comparing fermentation modes and their effects on proteinase yields. The vast diversity of lactobacilli proteinases represents an industrially feasible avenue for exploitation in biotechnological applications. Continued improvement of proteinase yields depends on a number of factors: identification of highly proteolytic strains, improvement of proteinase yields via optimisation of mediacomponent and process parameters and efficient product recovery. Successfully addressing these issues will require a multidisciplinary approach, encompassing fields such as microbiology, statistics and mathematical modelling and bioprocess engineering.
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Carbohydrate utilization affects Lactobacillus delbrueckii subsp. lactis 313 cell-enveloped-associated proteinase productionAgyei, D.; Danquah, Michael (2012)The effect of different sugars (glucose, glycerol, maltose, galactose and lactose) on cell-membrane-associated proteinase production by Lactobacillus delbrueckii subsp. lactis 313 (LDL 313) was investigated. The experimental ...
Optimisation of batch culture conditions for cell-envelope-associated proteinase production from lactobacillus delbrueckii subsp. lactis ATCC® 7830™Agyei, D.; Potumarthi, R.; Danquah, Michael (2012)Using a combination of conventional sequential techniques, the batch growth conditions for the production of cell-envelope-associated proteinases have for the first time been studied and optimised in Lactobacillus delbrueckii ...
Production of Lactobacilli Proteinases for the Manufacture of Bioactive Peptides: Part II-Downstream ProcessesAgyei, D.; Potumarthi, R.; Danquah, Michael (2013)This chapter deals with the downstream processes of lactobacilli proteinases recovery, isolation and purification strategies. One of the most pressing bioprocess challenges in the area of production of pharmaceutical/biological ...