Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Pigment epithelium-derived factor: a key mediator in bone homeostasis and potential for bone regenerative therapy

    Access Status
    Fulltext not available
    Authors
    Baxter-Holland, M.
    Dass, Crispin
    Date
    2018
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Baxter-Holland, M. and Dass, C. 2018. Pigment epithelium-derived factor: a key mediator in bone homeostasis and potential for bone regenerative therapy. Journal of Pharmacy and Pharmacology. 70 (9): pp. 1127-1138.
    Source Title
    Journal of Pharmacy and Pharmacology
    DOI
    10.1111/jphp.12942
    ISSN
    0022-3573
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/73327
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 Royal Pharmaceutical Society Objectives: Pigment epithelium-derived factor (PEDF), a multifunctional endogenous glycoprotein, has a very wide range of biological actions, notably in bone homeostasis. The question has been raised regarding the place of PEDF in the treatment of bone disorders and osteosarcoma, and its potential for tumour growth suppression. Methods: The PubMed database was used to compile this review. Key findings: Pigment epithelium-derived factor's actions in osteoid tissues include promoting mesenchymal stem cell commitment to osteoblasts, increasing matrix mineralisation, and promoting osteoblast proliferation. It shows potential to improve therapeutic outcomes in treatment of multiple cancer types and regrowth of bone after trauma or resection in animal studies. PEDF may possibly have a reduced adverse effect profile compared with current osteo-regenerative treatments; however, there is currently very limited evidence regarding the safety or efficacy in human models. Summary: Pigment epithelium-derived factor is very active within the body, particularly in osseous tissue, and its physiological actions give it potential for treatment of both bone disorders and multiple tumour types. Further research is needed to ascertain the adverse effects and safety profile of PEDF as a therapeutic agent.

    Related items

    Showing items related by title, author, creator and subject.

    • Systemically administered PEDF against primary and secondary tumours in a clinically relevant osteosarcoma model
      Broadhead, M.; Dass, Crispin; Choong, P. (2011)
      Background: Pigment epithelium-derived factor (PEDF) is an endogenous glycoprotein with a potential role as a therapeutic for osteosarcoma. Animal studies have demonstrated the biological effects of PEDF on osteosarcoma; ...
    • Stimulation of bone regeneration with pigment epithelium-derived factor microparticles: Evidence in silico, in vitro and in vivo
      Lee, P.; Martinez, Jorge; Dass, Crispin (2016)
      The occurrence of bone defects can be due to a variety of factors not limited to bone fractures and tumours. Most diseased bone is removed and the patient fitted with prosthetics, prior to use of certain factors such as ...
    • Alginate bead-encapsulated PEDF induces ectopic bone formation in vivo in the absence of co-administered mesenchymal stem cells.
      Elahy, M.; Doschak, M.; Hughes, J.; Baindur-Hudson, S.; Dass, Crispin (2015)
      Bone defects can be severely debilitating and reduce quality of life. Osteoregeneration can alleviate some of the complications in bony defects. For therapeutic use in future, a single factor that can cause potent bone ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.