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    A new measure of decompression sickness in the rat

    Access Status
    Fulltext not available
    Authors
    Buzzacott, Peter
    Mazur, A.
    Wang, Q.
    Lambrechts, K.
    Theron, M.
    Mansourati, J.
    Guerrero, F.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Buzzacott, P. and Mazur, A. and Wang, Q. and Lambrechts, K. and Theron, M. and Mansourati, J. and Guerrero, F. 2014. A new measure of decompression sickness in the rat. BioMed Research International. 2014.
    Source Title
    BioMed Research International
    DOI
    10.1155/2014/123581
    ISSN
    2314-6133
    School
    School of Nursing, Midwifery and Paramedicine
    URI
    http://hdl.handle.net/20.500.11937/73366
    Collection
    • Curtin Research Publications
    Abstract

    In this study we assessed the reliability of a tilting-board grip score as a measure of decompression sickness in rats. In experiments using a hyperbaric compression/decompression protocol, rats were observed for signs of decompression sickness and their grip strength measured on a tilting particle board hinged to a metal frame. Angles at which rats lost grip were converted to gravitational vectors. Decreased mean grip scores following decompression were fitted to a logistic regression model with strain, age, and weight. Decrease in grip score was significantly associated with observed decompression sickness (P=0.0036). The log odds ratio for decompression sickness = 1.40 (decrease in grip score). In rats with no decrease in mean grip score there was a 50% probability of decompression sickness (pDCS). This increased steadily with decreases in mean grip score. A decrease of 0.3 had a 60% pDCS, a decrease of 0.6 had a 70% pDCS, and a decrease of 2.1 had a 95% pDCS. The tilting board grip score is a reliable measure of the probability of decompression sickness. © 2014 Peter Buzzacott et al.

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