A new measure of decompression sickness in the rat
|dc.identifier.citation||Buzzacott, P. and Mazur, A. and Wang, Q. and Lambrechts, K. and Theron, M. and Mansourati, J. and Guerrero, F. 2014. A new measure of decompression sickness in the rat. BioMed Research International. 2014.|
In this study we assessed the reliability of a tilting-board grip score as a measure of decompression sickness in rats. In experiments using a hyperbaric compression/decompression protocol, rats were observed for signs of decompression sickness and their grip strength measured on a tilting particle board hinged to a metal frame. Angles at which rats lost grip were converted to gravitational vectors. Decreased mean grip scores following decompression were fitted to a logistic regression model with strain, age, and weight. Decrease in grip score was significantly associated with observed decompression sickness (P=0.0036). The log odds ratio for decompression sickness = 1.40 (decrease in grip score). In rats with no decrease in mean grip score there was a 50% probability of decompression sickness (pDCS). This increased steadily with decreases in mean grip score. A decrease of 0.3 had a 60% pDCS, a decrease of 0.6 had a 70% pDCS, and a decrease of 2.1 had a 95% pDCS. The tilting board grip score is a reliable measure of the probability of decompression sickness. © 2014 Peter Buzzacott et al.
|dc.publisher||Hindawi Publishing Corporation|
|dc.title||A new measure of decompression sickness in the rat|
|dcterms.source.title||BioMed Research International|
|curtin.department||School of Nursing, Midwifery and Paramedicine|
|curtin.accessStatus||Fulltext not available|
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