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    Alternative methods to animal studies for the evaluation of topical/transdermal drug delivery systems

    Access Status
    Fulltext not available
    Authors
    Junqueira Garcia, M.
    de Vasconcellos, F.
    Raffier, C.
    Roberts, M.
    Grice, J.
    Benson, Heather
    Leite-Silva, V.
    Date
    2018
    Type
    Journal Article
    
    Metadata
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    Citation
    Junqueira Garcia, M. and de Vasconcellos, F. and Raffier, C. and Roberts, M. and Grice, J. and Benson, H. and Leite-Silva, V. 2018. Alternative methods to animal studies for the evaluation of topical/transdermal drug delivery systems. Current Topics in Medicinal Chemistry. 18 (4): pp. 287-299.
    Source Title
    Current Topics in Medicinal Chemistry
    DOI
    10.2174/1568026618666180412153214
    ISSN
    1568-0266
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/74503
    Collection
    • Curtin Research Publications
    Abstract

    It is critical to develop an effective understanding of the interaction between the drug, delivery system and skin in order to predict and assess skin penetration and permeation. Experimental models for the assessment of topical and transdermal delivery systems must permit evaluation of these complex interactions. Whilst in the past, animal models were commonly used, recent regulatory guidelines, based on 3R principles (refinement, reduction, replacement), encourage the rational use of animals. Alternative methods have been proposed for use in the development of topical and transdermal delivery systems which are often used in combination. We will review the current state of the art in alternative methods for topical and transdermal delivery systems development, including technologies that can assist in the characterization of skin penetration/permeation studies.

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