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dc.contributor.authorJunqueira Garcia, M.
dc.contributor.authorde Vasconcellos, F.
dc.contributor.authorRaffier, C.
dc.contributor.authorRoberts, M.
dc.contributor.authorGrice, J.
dc.contributor.authorBenson, Heather
dc.contributor.authorLeite-Silva, V.
dc.date.accessioned2019-02-19T04:17:05Z
dc.date.available2019-02-19T04:17:05Z
dc.date.created2019-02-19T03:58:11Z
dc.date.issued2018
dc.identifier.citationJunqueira Garcia, M. and de Vasconcellos, F. and Raffier, C. and Roberts, M. and Grice, J. and Benson, H. and Leite-Silva, V. 2018. Alternative methods to animal studies for the evaluation of topical/transdermal drug delivery systems. Current Topics in Medicinal Chemistry. 18 (4): pp. 287-299.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/74503
dc.identifier.doi10.2174/1568026618666180412153214
dc.description.abstract

It is critical to develop an effective understanding of the interaction between the drug, delivery system and skin in order to predict and assess skin penetration and permeation. Experimental models for the assessment of topical and transdermal delivery systems must permit evaluation of these complex interactions. Whilst in the past, animal models were commonly used, recent regulatory guidelines, based on 3R principles (refinement, reduction, replacement), encourage the rational use of animals. Alternative methods have been proposed for use in the development of topical and transdermal delivery systems which are often used in combination. We will review the current state of the art in alternative methods for topical and transdermal delivery systems development, including technologies that can assist in the characterization of skin penetration/permeation studies.

dc.titleAlternative methods to animal studies for the evaluation of topical/transdermal drug delivery systems
dc.typeJournal Article
dcterms.source.volume18
dcterms.source.number4
dcterms.source.startPage287
dcterms.source.endPage299
dcterms.source.issn1568-0266
dcterms.source.titleCurrent Topics in Medicinal Chemistry
curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusFulltext not available


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