Show simple item record

dc.contributor.authorFehily, B.
dc.contributor.authorBartlett, C.
dc.contributor.authorLydiard, S.
dc.contributor.authorArcher, M.
dc.contributor.authorMilbourn, H.
dc.contributor.authorMajimbi, M.
dc.contributor.authorHemmi, J.
dc.contributor.authorDunlop, S.
dc.contributor.authorYates, N.
dc.contributor.authorFitzgerald, Melinda
dc.date.accessioned2019-02-19T04:17:17Z
dc.date.available2019-02-19T04:17:17Z
dc.date.created2019-02-19T03:58:08Z
dc.date.issued2019
dc.identifier.citationFehily, B. and Bartlett, C. and Lydiard, S. and Archer, M. and Milbourn, H. and Majimbi, M. and Hemmi, J. et al. 2019. Differential responses to increasing numbers of mild traumatic brain injury in a rodent closed head injury model. Journal of Neurochemistry. 149 (5): pp. 660-678.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/74531
dc.identifier.doi10.1111/jnc.14673
dc.description.abstract

Following mild traumatic brain injury (mTBI), further mild impacts can exacerbate negative outcomes. To compare chronic damage and deficits following increasing numbers of repeated mTBIs, a closed-head weight-drop model of repeated mTBI was used to deliver 1, 2 or 3 mTBIs to adult female rats at 24 h intervals. Outcomes were assessed at 3 months following the first mTBI. No gross motor, sensory or reflex deficits were identified (p > 0.05), consistent with current literature. Cognitive function assessed using a Morris water maze revealed chronic memory deficits following 1 and 2, but not 3 mTBI compared to shams (p = 0.05). Oxidative damage to DNA was assessed immunohistochemically in the dentate hilus of the hippocampus and splenium of the corpus callosum; no changes were observed. IBA1 positive microglia were increased in size in the cortex following 1 mTBI and in the corpus callosum following 2 mTBI compared to shams (p = 0.05); no changes were observed in the dentate hilus. GFAP positive astrocyte immunoreactivity was assessed in all three brain regions and no chronic changes were observed. Integrity of myelin ultrastructure in the corpus callosum was assessed using transmission electron microscopy. G ratio was decreased following 2 mTBIs compared to shams (p = 0.05) at post-hoc level only. The changing patterns of damage and deficits following increasing numbers of mTBI may reflect dynamic responses to small numbers of mTBIs or a conditioning effect such that increasing numbers of mild traumatic brain injuries do not necessarily result in worsening pathology.

dc.publisherWiley-Blackwell Publishing Ltd.
dc.titleDifferential responses to increasing numbers of mild traumatic brain injury in a rodent closed head injury model
dc.typeJournal Article
dcterms.source.issn1471-4159
dcterms.source.titleJournal of Neurochemistry
curtin.departmentHealth Sciences Research and Graduate Studies
curtin.accessStatusFulltext not available


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record