Formulation Development and Optimization for Transdermal Delivery of Peptide and Peptide Like Drugs

Abstract

This research focused on transdermal penetration enhancement of peptides, peptide-like and lipophilic drugs by employing physical and chemical penetration enhancers. Three potential physical penetration enhancement tools, namely elongated microparticles, microneedles and Dermaroller®, significantly increased in vitro skin penetration and retention with further enhancement achieved by formulating with a chemical enhancer. We concluded that physical and chemical penetration enhancers are suitable tools for transdermal drug delivery.