Formulation Development and Optimization for Transdermal Delivery of Peptide and Peptide Like Drugs
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This research focused on transdermal penetration enhancement of peptides, peptide-like and lipophilic drugs by employing physical and chemical penetration enhancers. Three potential physical penetration enhancement tools, namely elongated microparticles, microneedles and Dermaroller®, significantly increased in vitro skin penetration and retention with further enhancement achieved by formulating with a chemical enhancer. We concluded that physical and chemical penetration enhancers are suitable tools for transdermal drug delivery.
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Namjoshi, Sarika M (2009)Recent developments in genetic engineering and biotechnology have resulted in anincrease in availability of therapeutic peptides and small anti-cytokines. Oraladministration is inappropriate as these molecules are unstable ...
Mohammed, Yousuf; Yamada, M.; Lin, L.; Grice, J.; Roberts, M.; Raphael, A.; Benson, Heather; Prow, T. (2014)Peptides and proteins play an important role in skin health and well-being. They are also found to contribute to skin aging and melanogenesis. Microneedles have been shown to substantially enhance skin penetration and may ...
Krishnan, Gayathri (2011)Transdermal drug delivery is an effective alternative to conventional oral and injectable drug delivery routes. It offers painless and convenient once daily or even once weekly dosing for a variety of clinical indications. ...