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    Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs.

    76509.pdf (891.8Kb)
    Access Status
    Open access
    Authors
    Murphy, Riley
    Ramsay, Josh
    Lee, Y.
    Pang, S.
    O'Dea, M.
    Pearson, J.
    Axon, J.
    Raby, E.
    Abdulgader, S.
    Whitelaw, A.
    Coombs, G.
    Date
    2019
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Murphy, R.J. and Ramsay, J.P. and Lee, Y.T. and Pang, S. and O'Dea, M.A. and Pearson, J.C. and Axon, J.E. et al. 2019. Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs. International Journal of Antimicrobial Agents.
    Source Title
    International Journal of Antimicrobial Agents
    DOI
    10.1016/j.ijantimicag.2019.08.022
    ISSN
    0924-8579
    Faculty
    Faculty of Health Sciences
    School
    School of Pharmacy and Biomedical Sciences
    Funding and Sponsorship
    http://purl.org/au-research/grants/arc/FT170100235
    URI
    http://hdl.handle.net/20.500.11937/76269
    Collection
    • Curtin Research Publications
    Abstract

    Staphylococcus aureus is a serious human and animal pathogen. Multilocus sequence type 612 (ST612) is the dominant methicillin-resistant S. aureus (MRSA) clone in certain South African hospitals and is sporadically isolated from horses and horse-associated veterinarians in Australia. Colonization and infection by ST612-MRSA is increasing in Western Australia. Whole-genome sequencing was performed for 51 ST612-MRSA isolated from Western Australian patients and healthcare workers, South African hospital patients, Australian veterinarians and New South Wales horses. Core-genome phylogenies suggested Australian equine and veterinarian-associated ST612 were monophyletic. Individual Western Australian isolates grouped either with this equine-associated lineage or more diverse lineages related to those in South African hospitals. Bioinformatic analyses of the complete ST612-MRSA reference genome SVH7513 confirmed ST612-MRSA was closely related to ST8 USA500 MRSA. Common use of rifampicin in South Africa and equine veterinarian practice may favor ST612-MRSA in these settings. ST612-MRSA-colonized humans and horses are potential reservoirs for MRSA in Australia.

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