Show simple item record

dc.contributor.authorMurphy, Riley
dc.contributor.authorRamsay, Josh
dc.contributor.authorLee, Y.
dc.contributor.authorPang, S.
dc.contributor.authorO'Dea, M.
dc.contributor.authorPearson, J.
dc.contributor.authorAxon, J.
dc.contributor.authorRaby, E.
dc.contributor.authorAbdulgader, S.
dc.contributor.authorWhitelaw, A.
dc.contributor.authorCoombs, G.
dc.identifier.citationMurphy, R.J. and Ramsay, J.P. and Lee, Y.T. and Pang, S. and O'Dea, M.A. and Pearson, J.C. and Axon, J.E. et al. 2019. Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs. International Journal of Antimicrobial Agents.

Staphylococcus aureus is a serious human and animal pathogen. Multilocus sequence type 612 (ST612) is the dominant methicillin-resistant S. aureus (MRSA) clone in certain South African hospitals and is sporadically isolated from horses and horse-associated veterinarians in Australia. Colonization and infection by ST612-MRSA is increasing in Western Australia. Whole-genome sequencing was performed for 51 ST612-MRSA isolated from Western Australian patients and healthcare workers, South African hospital patients, Australian veterinarians and New South Wales horses. Core-genome phylogenies suggested Australian equine and veterinarian-associated ST612 were monophyletic. Individual Western Australian isolates grouped either with this equine-associated lineage or more diverse lineages related to those in South African hospitals. Bioinformatic analyses of the complete ST612-MRSA reference genome SVH7513 confirmed ST612-MRSA was closely related to ST8 USA500 MRSA. Common use of rifampicin in South Africa and equine veterinarian practice may favor ST612-MRSA in these settings. ST612-MRSA-colonized humans and horses are potential reservoirs for MRSA in Australia.

dc.subjectMethicillin-resistant Staphylococcus aureus
dc.subjectmolecular epidemiology
dc.titleMultiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs.
dc.typeJournal Article
dcterms.source.titleInternational Journal of Antimicrobial Agents
curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidRamsay, Josh [0000-0002-1301-7077]
curtin.contributor.scopusauthoridRamsay, Josh [8529700000]

Files in this item


This item appears in the following Collection(s)

Show simple item record