Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs.
|Murphy, R.J. and Ramsay, J.P. and Lee, Y.T. and Pang, S. and O'Dea, M.A. and Pearson, J.C. and Axon, J.E. et al. 2019. Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs. International Journal of Antimicrobial Agents.
Staphylococcus aureus is a serious human and animal pathogen. Multilocus sequence type 612 (ST612) is the dominant methicillin-resistant S. aureus (MRSA) clone in certain South African hospitals and is sporadically isolated from horses and horse-associated veterinarians in Australia. Colonization and infection by ST612-MRSA is increasing in Western Australia. Whole-genome sequencing was performed for 51 ST612-MRSA isolated from Western Australian patients and healthcare workers, South African hospital patients, Australian veterinarians and New South Wales horses. Core-genome phylogenies suggested Australian equine and veterinarian-associated ST612 were monophyletic. Individual Western Australian isolates grouped either with this equine-associated lineage or more diverse lineages related to those in South African hospitals. Bioinformatic analyses of the complete ST612-MRSA reference genome SVH7513 confirmed ST612-MRSA was closely related to ST8 USA500 MRSA. Common use of rifampicin in South Africa and equine veterinarian practice may favor ST612-MRSA in these settings. ST612-MRSA-colonized humans and horses are potential reservoirs for MRSA in Australia.
|Methicillin-resistant Staphylococcus aureus
|Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs.
|International Journal of Antimicrobial Agents
|School of Pharmacy and Biomedical Sciences
|Faculty of Health Sciences
|Ramsay, Josh [0000-0002-1301-7077]
|Ramsay, Josh