Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs.
dc.contributor.author | Murphy, Riley | |
dc.contributor.author | Ramsay, Josh | |
dc.contributor.author | Lee, Y. | |
dc.contributor.author | Pang, S. | |
dc.contributor.author | O'Dea, M. | |
dc.contributor.author | Pearson, J. | |
dc.contributor.author | Axon, J. | |
dc.contributor.author | Raby, E. | |
dc.contributor.author | Abdulgader, S. | |
dc.contributor.author | Whitelaw, A. | |
dc.contributor.author | Coombs, G. | |
dc.date.accessioned | 2019-09-11T03:05:35Z | |
dc.date.available | 2019-09-11T03:05:35Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Murphy, R.J. and Ramsay, J.P. and Lee, Y.T. and Pang, S. and O'Dea, M.A. and Pearson, J.C. and Axon, J.E. et al. 2019. Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs. International Journal of Antimicrobial Agents. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/76269 | |
dc.identifier.doi | 10.1016/j.ijantimicag.2019.08.022 | |
dc.description.abstract |
Staphylococcus aureus is a serious human and animal pathogen. Multilocus sequence type 612 (ST612) is the dominant methicillin-resistant S. aureus (MRSA) clone in certain South African hospitals and is sporadically isolated from horses and horse-associated veterinarians in Australia. Colonization and infection by ST612-MRSA is increasing in Western Australia. Whole-genome sequencing was performed for 51 ST612-MRSA isolated from Western Australian patients and healthcare workers, South African hospital patients, Australian veterinarians and New South Wales horses. Core-genome phylogenies suggested Australian equine and veterinarian-associated ST612 were monophyletic. Individual Western Australian isolates grouped either with this equine-associated lineage or more diverse lineages related to those in South African hospitals. Bioinformatic analyses of the complete ST612-MRSA reference genome SVH7513 confirmed ST612-MRSA was closely related to ST8 USA500 MRSA. Common use of rifampicin in South Africa and equine veterinarian practice may favor ST612-MRSA in these settings. ST612-MRSA-colonized humans and horses are potential reservoirs for MRSA in Australia. | |
dc.language | eng | |
dc.relation.sponsoredby | http://purl.org/au-research/grants/arc/FT170100235 | |
dc.subject | MRSA | |
dc.subject | Methicillin-resistant Staphylococcus aureus | |
dc.subject | bacteremia | |
dc.subject | equine | |
dc.subject | molecular epidemiology | |
dc.subject | zoonosis | |
dc.title | Multiple introductions of methicillin-resistant Staphylococcus aureus ST612 into Western Australia associated with both human and equine reservoirs. | |
dc.type | Journal Article | |
dcterms.source.issn | 0924-8579 | |
dcterms.source.title | International Journal of Antimicrobial Agents | |
dc.date.updated | 2019-09-11T03:05:35Z | |
curtin.department | School of Pharmacy and Biomedical Sciences | |
curtin.accessStatus | Open access | |
curtin.faculty | Faculty of Health Sciences | |
curtin.contributor.orcid | Ramsay, Josh [0000-0002-1301-7077] | |
dcterms.source.eissn | 1872-7913 | |
curtin.contributor.scopusauthorid | Ramsay, Josh [8529700000] |