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    Absence of MERS-CoV antibodies in feral camels in Australia: Implications for the pathogen's origin and spread

    234414_234414.pdf (609.7Kb)
    Access Status
    Open access
    Authors
    Crameri, G.
    Durr, P.
    Barr, J.
    Yu, M.
    Graham, K.
    Williams, O.
    Kayali, G.
    Smith, D.
    Peiris, M.
    Mackenzie, John
    Wang, L.
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Crameri, G. and Durr, P. and Barr, J. and Yu, M. and Graham, K. and Williams, O. and Kayali, G. et al. 2015. Absence of MERS-CoV antibodies in feral camels in Australia: Implications for the pathogen's origin and spread. One Health. 1: pp. 76-82.
    Source Title
    One Health
    DOI
    10.1016/j.onehlt.2015.10.003
    Faculty
    Faculty of Health Sciences
    Remarks

    This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by-nc-nd/4.0/

    URI
    http://hdl.handle.net/20.500.11937/7633
    Collection
    • Curtin Research Publications
    Abstract

    Middle East respiratory syndrome coronavirus (MERS-CoV) infections continue to be a serious emerging disease problem internationally with well over 1000 cases and a major outbreak outside of the Middle East region. While the hypothesis that dromedary camels are the likely major source of MERS-CoV infection in humans is gaining acceptance, conjecture continues over the original natural reservoir host(s) and specifically the role of bats in the emergence of the virus. Dromedary camels were imported to Australia, principally between 1880 and 1907 and have since become a large feral population inhabiting extensive parts of the continent. Here we report that during a focussed surveillance study, no serological evidence was found for the presence of MERS-CoV in the camels in the Australian population. This finding presents various hypotheses about the timing of the emergence and spread of MERS-CoV throughout populations of camels in Africa and Asia, which can be partially resolved by testing sera from camels from the original source region, which we have inferred was mainly northwestern Pakistan. In addition, we identify bat species which overlap (or neighbour) the range of the Australian camel population with a higher likelihood of carrying CoVs of the same lineage as MERS-CoV. Both of these proposed follow-on studies are examples of "proactive surveillance", a concept that has particular relevance to a One Health approach to emerging zoonotic diseases with a complex epidemiology and aetiology.

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