Traffic emissions are associated with reduced fetal growth in areas of Perth, Western Australia: An application of the AusRoads dispersion model
MetadataShow full item record
Background: This study, in a region with relatively low industrial activity, used a highly specific marker for traffic emissions, accounted for the inherent fetal growth potential, and used complete record linkage of births, midwife notifications, deaths, hospital morbidity and birth defect records. Methods: Clinical records were obtained for pregnancies between 2000 and 2006 in three areas of Perth, Western Australia (n=3,501). We used carbon monoxide as a marker for locally derived traffic emissions, and assessed exposure using the AusRoads dispersion model. Fetal growth was characterised by proportion of optimal birth weight and investigated using multivariate mixed-effects regression. Results: Exposure in the third trimester was associated with a -0.49% (sd=0.23%) change in proportion of optimal birth weight per 10 µg/m3 increase in locally derived traffic emissions. However, this result was confined to one of the three study areas due to elevated exposure misclassification among women in the other two areas. Among this group, a neonate who would have otherwise attained an optimal birth weight of 3.5 kg would be expected to be born 58 g lighter for an interquartile increase in third trimester exposure, which was approximately half of the effect observed for maternal smoking during pregnancy. Conclusion: We observed an association between maternal exposure to traffic emissions and reduced fetal growth. This effect was supported by sensitivity analyses but only observed in one of the three study areas. Further studies are required to corroborate our results.
Showing items related by title, author, creator and subject.
Locally derived traffic-related air pollution and fetal growth restriction: A retrospective cohort studyPereira, Gavin; Cook, A.; Haggar, F.; Bower, C.; Nassar, N. (2012)Background: Fetal growth restriction has been inconsistently associated with maternal exposure to elevated levels of traffic-related air pollution. Objective: We investigated the relationship between an individualised ...
Association between pre-eclampsia and locally derived traffic-related air pollution: A retrospective cohort studyPereira, Gavin; Haggar, F.; Shand, A.; Bower, C.; Cook, A.; Nassar, N. (2013)Background - Pre-eclampsia is a common complication of pregnancy and is a major cause of fetal–maternal mortality and morbidity. Despite a number of plausible mechanisms by which air pollutants might contribute to this ...
Risk of stillbirth, preterm delivery, and fetal growth restriction following exposure in a previous birth: Systematic review and meta-analysisMalacova, Eva; Regan, Annette; Nassar, N.; Raynes-Greenow, C.; Leonard, H.; Srinivasjois, R.; Shand, A.; Lavin, T.; Pereira, Gavin (2018)© 2018 Wolters Kluwer Health, Inc. All rights reserved. The leading cause of infant morbidity and mortality are stillbirth, preterm birth (PTB), and small for gestational age (SGA), which can occur as a result of fetal ...