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dc.contributor.authorElaskalani, Omar
dc.contributor.supervisorPat Metharomen_US
dc.date.accessioned2019-12-06T00:38:43Z
dc.date.available2019-12-06T00:38:43Z
dc.date.issued2019en_US
dc.identifier.urihttp://hdl.handle.net/20.500.11937/77186
dc.description.abstract

Platelets are small anucleate blood cells that are central to primary haemostasis. However, platelets are also implicated in cancer pathogenesis. This thesis showed that cancer cells promote thrombosis by activating platelets, and in turn, platelets provide cancer cells with growth factors to render cancer more aggressive and chemoresistant. The thesis demonstrated a therapeutic benefit of combined antiplatelet, ticagrelor, and chemo drugs, on cancer treatment.

en_US
dc.publisherCurtin Universityen_US
dc.titlePlatelet-cancer Crosstalk: Mechanisms and Therapeutic Implicationsen_US
dc.typeThesisen_US
dcterms.educationLevelPhDen_US
curtin.departmentSchool of Pharmacy and Biomedical Sciencesen_US
curtin.accessStatusOpen accessen_US
curtin.facultyHealth Sciencesen_US


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