Characterization of Ionic and Lipid Gradients within Corpus Callosum White Matter after Diffuse Traumatic Brain Injury in the Rat
Embargo Lift Date
MetadataShow full item record
Funding and Sponsorship
There is increased recognition of the effects of diffuse traumatic brain injury (dTBI), which can initiate yet unknown biochemical cascades, resulting in delayed secondary brain degeneration and long-term neurological sequela. There is limited availability of therapies that minimize the effect of secondary brain damage on the quality of life of people who have suffered TBI, many of which were otherwise healthy adults. Understanding the cascade of biochemical events initiated in specific brain regions in the acute phase of dTBI and how this spreads into adjacent brain structures may provide the necessary insight into drive development of improved therapies. In this study, we have used direct biochemical imaging techniques (Fourier transform infrared spectroscopic imaging) and elemental mapping (X-ray fluorescence microscopy) to characterize biochemical and elemental alterations that occur in corpus callosum white matter in the acute phase of dTBI. The results provide direct visualization of differential biochemical and ionic changes that occur in the highly vulnerable medial corpus callosum white matter relative to the less vulnerable lateral regions of the corpus callosum. Specifically, the results suggest that altered ionic gradients manifest within mechanically damaged medial corpus callosum, potentially spreading to and inducing lipid alterations to white matter structures in lateral brain regions.
Showing items related by title, author, creator and subject.
Volumetric neuroimaging of the Atlantic white-sided Dolphin (Lagenorhynchus acutus) brain from in situ magnetic resonance imagesMontie, E.; Schneider, G.; Ketten, Darlene; Marino, L.; Touhey, K.; Hahn, M. (2008)The structure and development of the brain are extremely difficult to study in free-ranging marine mammals. Here, we report measurements of total white matter (WM), total gray matter (GM), cerebellum (WM and GM), hippocampus, ...
White matter integrity in dyskinetic cerebral palsy: Relationship with intelligence quotient and executive functionLaporta-Hoyos, O.; Pannek, K.; Ballester-Plané, J.; Reid, L.; Vázquez, É.; Delgado, I.; Zubiaurre-Elorza, L.; Macaya, A.; Póo, P.; Meléndez-Plumed, M.; Junqué, C.; Boyd, Roslyn; Pueyo, R. (2017)Background: Dyskinetic cerebral palsy (CP) is one of the most disabling motor types of CP and has been classically associated with injury to the basal ganglia and thalamus. Although cognitive dysfunction is common in CP, ...
Bio-Spectroscopic Imaging Provides Evidence of Hippocampal Zn Deficiency and Decreased Lipid Unsaturation in an Accelerated Ageing Mouse ModelFimognari, Nicholas; Hollings, Ashley; Lam, Virginie; Tidy, Rebecca; Kewish, C.; Albrecht, Matthew; Takechi, Ryu; Mamo, John; Hackett, Mark (2018)© 2018 American Chemical Society. Western society is facing a health epidemic due to the increasing incidence of dementia in ageing populations, and there are still few effective diagnostic methods, minimal treatment ...