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    Altered brainstem anatomy in migraine

    Access Status
    Fulltext not available
    Authors
    Marciszewski, K.K.
    Meylakh, N.
    Harrington, Flavia
    Macefield, V.G.
    Macey, P.M.
    Henderson, L.A.
    Date
    2018
    Type
    Journal Article
    
    Metadata
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    Citation
    Marciszewski, K.K. and Meylakh, N. and Di Pietro, F. and Macefield, V.G. and Macey, P.M. and Henderson, L.A. 2018. Altered brainstem anatomy in migraine. Cephalalgia. 38 (3): pp. 476-486.
    Source Title
    Cephalalgia
    DOI
    10.1177/0333102417694884
    ISSN
    0333-1024
    Faculty
    Faculty of Health Sciences
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/79551
    Collection
    • Curtin Research Publications
    Abstract

    © International Headache Society 2017.

    Background: The exact mechanisms responsible for migraine remain unknown, although it has been proposed that changes in brainstem anatomy and function, even between attacks, may contribute to the initiation and maintenance of headache during migraine attacks. The aim of this investigation is to use brainstem-specific analyses of anatomical and diffusion weighted images to determine if the trigeminal system displays altered structure in individuals with migraine.

    Methods: Voxel-based morphometry of T1-weighted anatomical images (57 controls, 24 migraineurs) and diffusion tensor images (22 controls, 24 migraineurs) were used to assess brainstem anatomy in individuals with migraine compared with controls.

    Results: We found grey matter volume decreases in migraineurs in the spinal trigeminal nucleus and dorsomedial pons. In addition, reduced grey matter volume and increased free water diffusivity occurred in areas of the descending pain modulatory system, including midbrain periaqueductal gray matter, dorsolateral pons, and medullary raphe. These changes were not correlated to migraine frequency, duration, intensity or time to next migraine. Conclusion: Brainstem anatomy changes may underlie changes in activity that result in activation of the ascending trigeminal pathway and the perception of head pain during a migraine attack.

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