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dc.contributor.authorHenderson, L.A.
dc.contributor.authorDi Pietro, Flavia
dc.contributor.authorYoussef, A.M.
dc.contributor.authorLee, S.
dc.contributor.authorTam, S.
dc.contributor.authorAkhter, R.
dc.contributor.authorMills, E.P.
dc.contributor.authorMurray, G.M.
dc.contributor.authorPeck, C.C.
dc.contributor.authorMacey, P.M.
dc.date.accessioned2020-06-09T03:22:49Z
dc.date.available2020-06-09T03:22:49Z
dc.date.issued2020
dc.identifier.citationHenderson, L.A. and Di Pietro, F. and Youssef, A.M. and Lee, S. and Tam, S. and Akhter, R. and Mills, E.P. et al. 2020. Effect of Expectation on Pain Processing: A Psychophysics and Functional MRI Analysis. Frontiers in Neuroscience. 14: Article No. 6.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/79553
dc.identifier.doi10.3389/fnins.2020.00006
dc.description.abstract

© 2020 Henderson, Di Pietro, Youssef, Lee, Tam, Akhter, Mills, Murray, Peck and Macey. Pain is a complex phenomenon that is highly modifiable by expectation. Whilst the intensity of incoming noxious information plays a key role in the intensity of perceived pain, this intensity can be profoundly shaped by an individual’s expectations. Modern brain imaging investigations have begun to detail the brain regions responsible for placebo and nocebo related changes in pain, but less is known about the neural basis of stimulus-expectancy changes in pain processing. In this functional magnetic resonance imaging study, we administered two separate protocols of the same noxious thermal stimuli to 24 healthy subjects. However, different expectations were elicited by different explanations to subjects prior to each protocol. During one protocol, pain intensities were matched to expectation and in the other protocol they were not. Pain intensity was measured continuously via a manually operated computerized visual analogue scale. When individuals expected the stimulus intensity to remain constant, but in reality it was surreptitiously increased or decreased, pain intensity ratings were significantly lower than when expectation and pain intensities were matched. When the stimulus intensities did not match expectations, various areas in the brain such as the amygdala, anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (dlPFC), and the midbrain periaqueductal gray matter (PAG) displayed significantly different patterns of activity compared to instances when stimulus intensity and pain expectations were matched. These results show that stimulus-expectancy manipulation of pain intensity alters activity in both higher brain and brainstem centers which are known to modulate pain under various conditions.

dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.relation.sponsoredbyhttp://purl.org/au-research/grants/nhmrc/G182968
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectNeurosciences
dc.subjectNeurosciences & Neurology
dc.subjectpain expectations
dc.subjectpain intensity
dc.subjectfunctional magnetic resonance imaging
dc.subjectpain modulation
dc.subjectsomatosensory cortex
dc.subjectPREFRONTAL CORTEX
dc.subjectMODULATION
dc.subjectFMRI
dc.subjectANTICIPATION
dc.subjectEXPERIENCE
dc.subjectMEDULLA
dc.subjectEMOTION
dc.subjectNEURONS
dc.subjectCUE
dc.titleEffect of Expectation on Pain Processing: A Psychophysics and Functional MRI Analysis
dc.typeJournal Article
dcterms.source.volume14
dcterms.source.issn1662-4548
dcterms.source.titleFrontiers in Neuroscience
dc.date.updated2020-06-09T03:22:43Z
curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidDi Pietro, Flavia [0000-0002-9642-0805]
curtin.contributor.researcheridDi Pietro, Flavia [P-5415-2018]
curtin.identifier.article-numberARTN 6
dcterms.source.eissn1662-453X
curtin.contributor.scopusauthoridDi Pietro, Flavia [6603432291]


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