Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Altered regional cerebral blood flow and hypothalamic connectivity immediately prior to a migraine headache

    Access Status
    Fulltext not available
    Authors
    Meylakh, N.
    Marciszewski, K.K.
    Di Pietro, Flavia
    Macefield, V.G.
    Macey, P.M.
    Henderson, L.A.
    Date
    2020
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Meylakh, N. and Marciszewski, K.K. and Di Pietro, F. and Macefield, V.G. and Macey, P.M. and Henderson, L.A. 2020. Altered regional cerebral blood flow and hypothalamic connectivity immediately prior to a migraine headache. Cephalalgia. 40 (5): pp. 448-460.
    Source Title
    Cephalalgia
    DOI
    10.1177/0333102420911623
    ISSN
    0333-1024
    Faculty
    Faculty of Health Sciences
    School
    School of Pharmacy and Biomedical Sciences
    Funding and Sponsorship
    http://purl.org/au-research/grants/nhmrc/1032072
    http://purl.org/au-research/grants/nhmrc/1059182
    URI
    http://hdl.handle.net/20.500.11937/79554
    Collection
    • Curtin Research Publications
    Abstract

    © International Headache Society 2020. Background: There is evidence of altered resting hypothalamic activity patterns and connectivity prior to a migraine, however it remains unknown if these changes are driven by changes in overall hypothalamic activity levels. If they are, it would corroborate the idea that changes in hypothalamic function result in alteration in brainstem pain processing sensitivity, which either triggers a migraine headache itself or allows an external trigger to initiate a migraine headache. We hypothesise that hypothalamic activity increases immediately prior to a migraine headache and this is accompanied by altered functional connectivity to pain processing sites in the brainstem. Methods: In 34 migraineurs and 26 healthy controls, we collected a series comprising 108 pseudo-continuous arterial spin labelling images and 180 gradient-echo echo planar resting-state functional magnetic resonance volumes to measure resting regional cerebral blood flow and functional connectivity respectively. Images were pre-processed and analysed using custom SPM12 and Matlab software. Results: Our results reflect that immediately prior to a migraine headache, resting regional cerebral blood flow decreases in the lateral hypothalamus. In addition, resting functional connectivity strength decreased between the lateral hypothalamus and important regions of the pain processing pathway, such as the midbrain periaqueductal gray, dorsal pons, rostral ventromedial medulla and cingulate cortex, only during this critical period before a migraine headache. Conclusion: These data suggest altered hypothalamic function and connectivity in the period immediately prior to a migraine headache and supports the hypothesis that the hypothalamus is involved in migraine initiation.

    Related items

    Showing items related by title, author, creator and subject.

    • Deep in the brain: Changes in subcortical function immediately preceding a migraine attack
      Meylakh, N.; Marciszewski, K.K.; Harrington, Flavia ; Macefield, V.G.; Macey, P.M.; Henderson, L.A. (2018)
      © 2018 Wiley Periodicals, Inc. The neural mechanism responsible for migraine remains unclear. While the role of an external trigger in migraine initiation remains vigorously debated, it is generally assumed that migraineurs ...
    • Changes in brainstem pain modulation circuitry function over the migraine cycle
      Marciszewski, K.K.; Meylakh, N.; Harrington, Flavia ; Mills, E.P.; Macefield, V.G.; Macey, P.M.; Henderson, L.A. (2018)
      © 2018 the authors. The neural mechanism responsible for migraine remains unclear. While an external trigger has been proposed to initiate a migraine, it has also been proposed that changes in brainstem function are ...
    • Fluctuating regional brainstem diffusion imaging measures of microstructure across the migraine cycle
      Marciszewski, K.K.; Meylakh, N.; Di Pietro, Flavia ; Macefield, V.G.; Macey, P.M.; Henderson, L.A. (2019)
      © 2019 Marciszewski et al. The neural mechanisms responsible for the initiation and expression of migraines remain unknown. Although there is growing evidence of changes in brainstem anatomy and function between attacks, ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.