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    Deep in the brain: Changes in subcortical function immediately preceding a migraine attack

    Access Status
    Fulltext not available
    Authors
    Meylakh, N.
    Marciszewski, K.K.
    Harrington, Flavia
    Macefield, V.G.
    Macey, P.M.
    Henderson, L.A.
    Date
    2018
    Type
    Journal Article
    
    Metadata
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    Citation
    Meylakh, N. and Marciszewski, K.K. and Di Pietro, F. and Macefield, V.G. and Macey, P.M. and Henderson, L.A. 2018. Deep in the brain: Changes in subcortical function immediately preceding a migraine attack. Human Brain Mapping. 39 (6): pp. 2651-2663.
    Source Title
    Human Brain Mapping
    DOI
    10.1002/hbm.24030
    ISSN
    1065-9471
    Faculty
    Faculty of Health Sciences
    School
    School of Pharmacy and Biomedical Sciences
    Funding and Sponsorship
    http://purl.org/au-research/grants/nhmrc/1032072
    http://purl.org/au-research/grants/nhmrc/1059182
    URI
    http://hdl.handle.net/20.500.11937/79560
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 Wiley Periodicals, Inc.

    The neural mechanism responsible for migraine remains unclear. While the role of an external trigger in migraine initiation remains vigorously debated, it is generally assumed that migraineurs display altered brain function between attacks. This idea stems from relatively few brain imaging studies with even fewer studies exploring changes in the 24 h period immediately prior to a migraine attack. Using functional magnetic resonance imaging, we measured infra-slow oscillatory activity, regional homogeneity, and connectivity strengths of resting activity in migraineurs directly before (n = 8), after (n = 11), and between migraine attacks (n = 26) and in healthy control subjects (n = 78). Comparisons between controls and each migraine group and between migraine groups were made for each of these measures. Directly prior to a migraine, increased infra-slow oscillatory activity occurred in brainstem and hypothalamic regions that also display altered activity during a migraine itself, that is, the spinal trigeminal nucleus, dorsal pons, and hypothalamus. Furthermore, these midbrain and hypothalamic sites displayed increased connectivity strengths and regional homogeneity directly prior to a migraine. Remarkably, these resting oscillatory and connectivity changes did not occur directly after or between migraine attacks and were significantly different to control subjects. These data provide evidence of altered brainstem and hypothalamic function in the period immediately before a migraine and raise the prospect that such changes contribute to the expression of a migraine attack.

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