The inhibitory properties of acidic functionalised calixarenes on human papillomavirus pentamer formation
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This is an accepted manuscript of an article published by Taylor & Francis in Supramolecular Chemsitry on 03/07/2020 available online at http://www.tandfonline.com/10.1080/10610278.2020.1779930.
© 2020 Informa UK Limited, trading as Taylor & Francis Group. Human Papillomavirus (HPV) is the leading cause of cervical cancer, with only some HPV types prevented with vaccines and no treatments for the viral infection itself. One way to target viral infection is by inhibiting the assembly of the L1 monomer into a pentamer, which forms the viral capsid. Four calixarene compounds functionalised with D- and L-aspartic and glutamic acid and an iminodiacetic functionalised calixarene were synthesised and tested for L1 pentamer formation inhibition. The amino acid functionalised calixarene derivatives showed millimolar inhibition (IC50 = 0.72 to 2.67 mM) of pentamer formation, with little difference between the stereoisomers. The iminodiacetic acid calixarene derivative showed no inhibitory properties, despite sharing structural similarities with the four other calixarenes. Confirmation of binding the negatively charged compounds to the positive residues of the L1 protein was achieved by trypsin digestion. This study is helpful in the development of cost-effective inhibitors to prevent HPV assembly.
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