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dc.contributor.authorGoh, Ching Yong
dc.contributor.authorFu, D.Y.
dc.contributor.authorDuncan, Caitlin
dc.contributor.authorTinker, Adam
dc.contributor.authorLi, F.
dc.contributor.authorMocerino, Mauro
dc.contributor.authorOgden, Mark
dc.contributor.authorWu, Y.
dc.date.accessioned2020-07-30T04:27:20Z
dc.date.available2020-07-30T04:27:20Z
dc.date.issued2020
dc.identifier.citationGoh, C.Y. and Fu, D.Y. and Duncan, C.L. and Tinker, A. and Li, F. and Mocerino, M. and Ogden, M.I. et al. 2020. The inhibitory properties of acidic functionalised calix[4]arenes on human papillomavirus pentamer formation. Supramolecular Chemistry. 32 (5): pp. 345-353.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/80239
dc.identifier.doi10.1080/10610278.2020.1779930
dc.description.abstract

© 2020 Informa UK Limited, trading as Taylor & Francis Group. Human Papillomavirus (HPV) is the leading cause of cervical cancer, with only some HPV types prevented with vaccines and no treatments for the viral infection itself. One way to target viral infection is by inhibiting the assembly of the L1 monomer into a pentamer, which forms the viral capsid. Four calix[4]arene compounds functionalised with D- and L-aspartic and glutamic acid and an iminodiacetic functionalised calix[4]arene were synthesised and tested for L1 pentamer formation inhibition. The amino acid functionalised calix[4]arene derivatives showed millimolar inhibition (IC50 = 0.72 to 2.67 mM) of pentamer formation, with little difference between the stereoisomers. The iminodiacetic acid calix[4]arene derivative showed no inhibitory properties, despite sharing structural similarities with the four other calix[4]arenes. Confirmation of binding the negatively charged compounds to the positive residues of the L1 protein was achieved by trypsin digestion. This study is helpful in the development of cost-effective inhibitors to prevent HPV assembly.

dc.languageEnglish
dc.publisherTAYLOR & FRANCIS LTD
dc.subjectScience & Technology
dc.subjectPhysical Sciences
dc.subjectChemistry, Multidisciplinary
dc.subjectChemistry
dc.subjectCalixarene
dc.subjecthuman papillomavirus
dc.subjectassembly inhibitor
dc.subjectL1 pentamer
dc.subjectamino acid
dc.subjectCAPSID PROTEIN
dc.subjectCALIXARENE
dc.subjectAGENTS
dc.titleThe inhibitory properties of acidic functionalised calix[4]arenes on human papillomavirus pentamer formation
dc.typeJournal Article
dcterms.source.startPage1
dcterms.source.endPage9
dcterms.source.issn1061-0278
dcterms.source.titleSupramolecular Chemistry
dc.date.updated2020-07-30T04:27:19Z
curtin.note

This is an accepted manuscript of an article published by Taylor & Francis in Supramolecular Chemsitry on 03/07/2020 available online at http://www.tandfonline.com/10.1080/10610278.2020.1779930.

curtin.departmentSchool of Molecular and Life Sciences (MLS)
curtin.accessStatusOpen access
curtin.facultyFaculty of Science and Engineering
curtin.contributor.orcidOgden, Mark [0000-0001-5317-1637]
curtin.contributor.orcidMocerino, Mauro [0000-0001-9514-7846]
curtin.contributor.researcheridMocerino, Mauro [B-2793-2011]
dcterms.source.eissn1029-0478
curtin.contributor.scopusauthoridOgden, Mark [7005364420]
curtin.contributor.scopusauthoridMocerino, Mauro [6603180005]


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