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    Confounding effects of gavage in mice: Impaired respiratory structure and function

    Access Status
    Fulltext not available
    Authors
    Larcombe, Alexander
    Wang, K.C.W.
    Phan, J.A.
    Berry, L.J.
    Noble, P.B.
    Date
    2019
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Larcombe, A.N. and Wang, K.C.W. and Phan, J.A. and Berry, L.J. and Noble, P.B. 2019. Confounding effects of gavage in mice: Impaired respiratory structure and function. American Journal of Respiratory Cell and Molecular Biology. 61 (6): pp. 791-794.
    Source Title
    American Journal of Respiratory Cell and Molecular Biology
    DOI
    10.1165/rcmb.2019-0242LE
    ISSN
    1044-1549
    Faculty
    Faculty of Health Sciences
    School
    School of Public Health
    Funding and Sponsorship
    http://purl.org/au-research/grants/nhmrc/1128231
    http://purl.org/au-research/grants/nhmrc/1090888
    URI
    http://hdl.handle.net/20.500.11937/80322
    Collection
    • Curtin Research Publications
    Abstract

    The authors talk about the confounding effects of gavage in mice. He said that gavage is the most widely used method for precise oral dosing in experimental studies involving rodents. In the hands of a skilled operator, the procedure is rapid and allows for a precise volume of a substance to be delivered directly to the stomach, where it can be absorbed. Gavage is advantageous in situations where the substance to be delivered cannot be incorporated into feed or is unpalatable. Of particular interest to the current readership is the common use of gavage in studies with a respiratory focus.

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