Synthesis of Distally‐Bridged Chiral Resorcinarene Crowns.
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Mocerino, M. and Tan, D.A. and McIldowie, M.J. and Massera, C. 2020. Synthesis of Distally‐Bridged Chiral Resorcinarene Crowns. European Journal of Organic Chemistry.
European Journal of Organic Chemistry
Faculty of Science and Engineering
School of Molecular and Life Sciences (MLS)
Our interest in the potential of chiral tetramethoxy-resorcinarene as agents for chiral recognition has led us to synthesise twelve distally-bridged chiral resorcinarene crowns. The fascinating architecture of these partially-enclosed chiral basket molecules is evident in the solid-state structures which have been determined by single crystal X-ray crystallography. Moreover, the enantiomers of these chiral resorcinarene crowns have been resolved via diastereomeric resolution, with the absolute configuration of the diastereomers being determined by X-ray crystallography. This work enables further exploration of these enantio-pure chiral baskets as possible chiral resolving agents.
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