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dc.contributor.authorKo, Humphrey H.T.
dc.contributor.authorLareu, Ricky
dc.contributor.authorDix, Brett
dc.contributor.authorHughes, Jeffery
dc.contributor.authorParsons, Richard
dc.date.accessioned2020-09-03T02:22:55Z
dc.date.available2020-09-03T02:22:55Z
dc.date.issued2019
dc.identifier.citationKo, H.H.T. and Lareu, R.R. and Dix, B.R. and Hughes, J.D. and Parsons, R.W. 2019. A sequence symmetry analysis of the interrelationships between statins, diabetes and skin infections. British Journal of Clinical Pharmacology. 85 (11): pp. 2559-2567.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/80905
dc.identifier.doi10.1111/bcp.14077
dc.description.abstract

© 2019 The British Pharmacological Society

Aims: To determine statins' impact on skin infection risk in view of conflicting literature: that statins may reduce infection risk, but are also associated with diabetes mellitus, a risk factor for skin and soft tissue infections (SSTIs).

Methods: Sequence symmetry analysis was performed on prescription claims (2001–2011) from the Australian Department of Veterans' Affairs to determine the interrelationships between: (i) statins and SSTIs; (ii) statins and diabetes; and (iii) diabetes and SSTIs; as well as whether statins increased the risk of SSTIs, independent of diabetes status. Chi-square tests were performed to detect differences in Index of Relative Socio-economic Advantage and Disadvantage scores of patients within each interrelationship. Prescriptions for statins, antidiabetic medication, and antistaphylococcal antibiotics were evaluated using nonidentifiable client numbers, prescription dates filled, residential electorates, and pharmaceutical codes. Adjusted sequence ratio and confidence interval were calculated at intervals of 91, 182 and 365 days for sequence symmetry analysis studies.

Results: Statins were associated with: (i) significant SSTI risk (adjusted sequence ratio > 1; confidence interval >1), (ii) significant diabetes risk, and (iii) diabetic patients had increased risk of SSTIs. Diabetic and nondiabetic statin users had significantly increased risks of SSTIs, while the influence from socioeconomic status was not significant for each of the 3 relationships.

Conclusions: Statins are associated with increased risk of SSTIs via direct and indirect mechanisms, probably independent of diabetes or socioeconomic statuses. We believe that clinicians should be aware of the association between statins and SSTIs, and, where appropriate, monitor blood glucose levels of statin users.

dc.languageEnglish
dc.publisherWILEY
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectPharmacology & Pharmacy
dc.subjectantibiotics
dc.subjectdiabetes
dc.subjectpharmacoepidemiology
dc.subjectstatins
dc.subjectCOA REDUCTASE INHIBITORS
dc.subjectSOFT-TISSUE INFECTIONS
dc.subjectVITAMIN-D
dc.subjectBACTERIAL SKIN
dc.subjectGUT DYSBIOSIS
dc.subjectPRESCRIPTION
dc.subjectTHERAPY
dc.subjectRISK
dc.subjectEPIDEMIOLOGY
dc.titleA sequence symmetry analysis of the interrelationships between statins, diabetes and skin infections
dc.typeJournal Article
dcterms.source.volume85
dcterms.source.number11
dcterms.source.startPage2559
dcterms.source.endPage2567
dcterms.source.issn0306-5251
dcterms.source.titleBritish Journal of Clinical Pharmacology
dc.date.updated2020-09-03T02:22:55Z
curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidLareu, Ricky [0000-0002-8767-3499]
curtin.contributor.orcidKo, Humphrey H.T. [0000-0003-3107-4240]
dcterms.source.eissn1365-2125
curtin.contributor.scopusauthoridLareu, Ricky [6507590383]
curtin.contributor.scopusauthoridHughes, Jeffery [55241561700]


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