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    Acute stress, but not corticosterone, facilitates acquisition of paired associates learning in rats using touchscreen-equipped operant conditioning chambers

    Access Status
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    Authors
    Roebuck, A.J.
    Liu, M.C.
    Lins, Brittney
    Scott, G.A.
    Howland, J.G.
    Date
    2018
    Type
    Journal Article
    
    Metadata
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    Citation
    Roebuck, A.J. and Liu, M.C. and Lins, B.R. and Scott, G.A. and Howland, J.G. 2018. Acute stress, but not corticosterone, facilitates acquisition of paired associates learning in rats using touchscreen-equipped operant conditioning chambers. Behavioural Brain Research. 348: pp. 139-149.
    Source Title
    Behavioural Brain Research
    DOI
    10.1016/j.bbr.2018.04.027
    ISSN
    0166-4328
    Faculty
    Faculty of Health Sciences
    School
    Health Sciences Research and Graduate Studies
    URI
    http://hdl.handle.net/20.500.11937/81118
    Collection
    • Curtin Research Publications
    Abstract

    © 2018 Elsevier B.V. Acute stress influences learning and memory in humans and rodents, enhancing performance in some tasks while impairing it in others. Typically, subjects preferentially employ striatal-mediated stimulus-response strategies in spatial memory tasks following stress, making use of fewer hippocampal-based strategies which may be more cognitively demanding. Previous research demonstrated that the acquisition of rodent paired associates learning (PAL) relies primarily on the striatum, while task performance after extensive training is impaired by hippocampal disruption. Therefore, we sought to explore whether the acquisition of PAL, an operant conditioning task involving spatial stimuli, could be enhanced by acute stress. Male Long-Evans rats were trained to a predefined criterion in PAL and then subjected to either a single session of restraint stress (30 min) or injection of corticosterone (CORT; 3 mg/kg). Subsequent task performance was monitored for one week. We found that rats subjected to restraint stress, but not those rats injected with CORT, performed with higher accuracy and efficiency, when compared to untreated controls. These results suggest that while acute stress enhances the acquisition of PAL, CORT alone does not. This dissociation may be due to differences between these treatments and their ability to produce sufficient catecholamine release in the amygdala, a requirement for stress effects on memory.

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