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dc.contributor.authorRoebuck, A.J.
dc.contributor.authorLiu, M.C.
dc.contributor.authorLins, Brittney
dc.contributor.authorScott, G.A.
dc.contributor.authorHowland, J.G.
dc.date.accessioned2020-09-23T01:46:10Z
dc.date.available2020-09-23T01:46:10Z
dc.date.issued2018
dc.identifier.citationRoebuck, A.J. and Liu, M.C. and Lins, B.R. and Scott, G.A. and Howland, J.G. 2018. Acute stress, but not corticosterone, facilitates acquisition of paired associates learning in rats using touchscreen-equipped operant conditioning chambers. Behavioural Brain Research. 348: pp. 139-149.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/81118
dc.identifier.doi10.1016/j.bbr.2018.04.027
dc.description.abstract

© 2018 Elsevier B.V. Acute stress influences learning and memory in humans and rodents, enhancing performance in some tasks while impairing it in others. Typically, subjects preferentially employ striatal-mediated stimulus-response strategies in spatial memory tasks following stress, making use of fewer hippocampal-based strategies which may be more cognitively demanding. Previous research demonstrated that the acquisition of rodent paired associates learning (PAL) relies primarily on the striatum, while task performance after extensive training is impaired by hippocampal disruption. Therefore, we sought to explore whether the acquisition of PAL, an operant conditioning task involving spatial stimuli, could be enhanced by acute stress. Male Long-Evans rats were trained to a predefined criterion in PAL and then subjected to either a single session of restraint stress (30 min) or injection of corticosterone (CORT; 3 mg/kg). Subsequent task performance was monitored for one week. We found that rats subjected to restraint stress, but not those rats injected with CORT, performed with higher accuracy and efficiency, when compared to untreated controls. These results suggest that while acute stress enhances the acquisition of PAL, CORT alone does not. This dissociation may be due to differences between these treatments and their ability to produce sufficient catecholamine release in the amygdala, a requirement for stress effects on memory.

dc.languageeng
dc.subjectGlucocorticoid
dc.subjectHippocampus
dc.subjectRestraint stress
dc.subjectStrategy
dc.subjectStriatum
dc.subjectAnimals
dc.subjectAssociation Learning
dc.subjectConditioning, Operant
dc.subjectCorpus Striatum
dc.subjectCorticosterone
dc.subjectHippocampus
dc.subjectLearning
dc.subjectMale
dc.subjectMemory
dc.subjectPaired-Associate Learning
dc.subjectRats
dc.subjectRats, Long-Evans
dc.subjectStress Disorders, Traumatic, Acute
dc.titleAcute stress, but not corticosterone, facilitates acquisition of paired associates learning in rats using touchscreen-equipped operant conditioning chambers
dc.typeJournal Article
dcterms.source.volume348
dcterms.source.startPage139
dcterms.source.endPage149
dcterms.source.issn0166-4328
dcterms.source.titleBehavioural Brain Research
dc.date.updated2020-09-23T01:46:10Z
curtin.departmentHealth Sciences Research and Graduate Studies
curtin.accessStatusFulltext not available
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidLins, Brittney [0000-0002-7960-7782]
dcterms.source.eissn1872-7549
curtin.contributor.scopusauthoridLins, Brittney [55978122000]


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