Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia
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2021-08-01
Authors
Mowlaboccus, S.
Daley, D.
Pang, S.
Gottlieb, T.
Merlino, J.
Nimmo, G.R.
George, N.
Korman, T.M.
Streitberg, R.
Robson, J.
Peachey, G.
Collignon, P.
Bradbury, S.
Colombi, Elena
Ramsay, Josh
Rogers, B.A.
Coombs, G.W.
Date
2020Type
Journal Article
Metadata
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Mowlaboccus, S. and Daley, D. and Pang, S. and Gottlieb, T. and Merlino, J. and Nimmo, G.R. and George, N. et al. 2020. Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia. International Journal of Antimicrobial Agents. 56 (4): Article No. 106121.
Source Title
International Journal of Antimicrobial Agents
ISSN
Faculty
Faculty of Health Sciences
School
School of Pharmacy and Biomedical Sciences
Collection
Abstract
© 2020 Elsevier Ltd
Of 1033 Escherichia coli urinary tract infection isolates collected from females >12 years of age in Australia in 2019, only 2 isolates were resistant to fosfomycin with a minimum inhibitory concentration (MIC) of >256 mg/L. Despite having different multilocus sequence types, the two isolates harboured an identical plasmid-encoded fosA4 gene. The fosA4 gene has previously been identified in a single clinical E. coli isolate cultured in Japan in 2014. Each fosfomycin-resistant isolate harboured two conjugative plasmids that possessed an array of genes conferring resistance to aminoglycosides, β-lactams, macrolides, quinolones, sulfonamides and/or trimethoprim.