Syringomyelia: A review of the biomechanics
MetadataShow full item record
Syringomyelia is a neurological disorder caused by the development of one or more macroscopic fluid-filled cavities in the spinal cord. While the aetiology remains uncertain, hydrodynamics appear to play a role. This has led to the involvement of engineers, who have modelled the system in silico and on the bench. In the process, hypotheses from the neurosurgical literature have been tested, and others generated, while aspects of the system mechanics have been clarified. The spinal cord is surrounded by cerebrospinal fluid (CSF) which is subject both to the periodic excitation of CSF expelled from the head with each heartbeat, and to intermittent larger transients from cough, sneeze, etc., via vertebral veins. The resulting pulsatile flow and pressure wave propagation, and their possible effects on cord cavities and cord stresses, have been elucidated. These engineering contributions are here reviewed for the first time.
NOTICE: This is the author’s version of a work that was accepted for publication in Journal of Fluids and Structures. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Fluids and Structures, Volume 40, July 2013, Pages 1-24. http://dx.doi.org/10.1016/j.jfluidstructs.2013.01.010
Showing items related by title, author, creator and subject.
Fluid–structure interactions in a cylindrical layered wave guide with application in the spinal column to syringomyeliaElliott, N.; Lucey, Anthony; Lockerby, D.; Brodbelt, A. (2017)© 2016Syringomyelia is a disease of the spinal cord in which fluid-filled cavities, called syrinxes, form and expand, compressing the surrounding neural tissue and producing neurological damage. This condition can occur ...
The organization of spinal motor neurons in a monotreme is consistent with a six-region schema of the mammalian spinal cordMitchelle, A.; Watson, Charles (2016)The motor neurons in the spinal cord of an echidna (Tachyglossus aculeatus) have been mapped in Nissl-stained sections from spinal cord segments defined by spinal nerve anatomy. A medial motor column of motor neurons is ...
Sengul, G.; Puchalski, R.; Watson, Charles (2012)Interpretation of the new wealth of gene expression and molecular mechanisms in the developing mouse spinal cord requires an accurate anatomical base on which data can be mapped. Therefore, we have assembled a spinal cord ...