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dc.contributor.authorMooranian, Armin
dc.contributor.authorZamani, Nassim
dc.contributor.authorTakechi, Ryu
dc.contributor.authorLuna, Giuseppe
dc.contributor.authorMikov, M.
dc.contributor.authorGoločorbin-Kon, S.
dc.contributor.authorElnashar, Magdy
dc.contributor.authorArfuso, Frank
dc.contributor.authorAl-Salami, Hani
dc.date.accessioned2021-01-20T03:46:36Z
dc.date.available2021-01-20T03:46:36Z
dc.date.issued2019
dc.identifier.citationMooranian, A. and Zamani, N. and Takechi, R. and Luna, G. and Mikov, M. and Goločorbin-Kon, S. and Elnashar, M. et al. 2019. An in vivo pharmacological study: Variation in tissue-accumulation for the drug probucol as the result of targeted microtechnology and matrix-acrylic acid optimization and stabilization techniques. PLoS ONE. 14 (4): Article No. e0214984.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/82373
dc.identifier.doi10.1371/journal.pone.0214984
dc.description.abstract

© 2019 Mooranian et al. Type 2 diabetes (T2D) is characterised by β-cell damage and hyperglycaemia. The lipophilic drug, probucol, has shown significant β-cell protective and potential antidiabetic effects, which were enhanced by hydrophilic bile acid incorporation using taurocholic acid and chenodeoxycholic acid. However, probucol has severe cardiotoxicity and a variable absorption profile, which limit its potential applications in T2D. Accordingly, this study aimed to design multiple formulations to optimise probucol oral delivery in T2D and test their effects on probucol absorption and accumulation in the heart. Adult male mice were given a high fat diet (HFD), and a week later, injected with a single dose of alloxan to accelerate T2D development, and once diabetes confirmed, divided into three groups (six to seven mice each). The groups were gavaged a daily dose of probucol powder, probucol microcapsules, or probucol-bile acid microcapsules for three months, and euthanized; and blood, tissues, and feces collected for blood glucose and probucol concentration analyses. Probucol concentrations in plasma were similar among all the groups. Groups given probucol microcapsules and probucol-bile acid microcapsules showed significant reduction in probucol accumulation in the heart compared with the group given probucol powder (p<0.05). Probucol microencapsulation with or without bile acids reduced its accumulation in heart tissues, without changing plasma concentrations, which may be beneficial in reducing its cardiotoxicity and optimise its potential applications in T2D.

dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectScience & Technology
dc.subjectMultidisciplinary Sciences
dc.subjectScience & Technology - Other Topics
dc.subjectPOTENTIAL ANTIDIABETIC DRUG
dc.subjectBILE-ACID
dc.subjectINSULIN SENSITIVITY
dc.subjectDELIVERY
dc.subjectMICROENCAPSULATION
dc.subjectFORMULATION
dc.subjectMICROCAPSULES
dc.subjectMUSCLES
dc.subjectSTRESS
dc.titleAn in vivo pharmacological study: Variation in tissue-accumulation for the drug probucol as the result of targeted microtechnology and matrix-acrylic acid optimization and stabilization techniques
dc.typeJournal Article
dcterms.source.volume14
dcterms.source.number4
dcterms.source.issn1932-6203
dcterms.source.titlePLoS ONE
dc.date.updated2021-01-20T03:46:31Z
curtin.departmentCurtin Medical School
curtin.departmentCurtin School of Population Health
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidMooranian, Armin [0000-0001-7103-2067]
curtin.contributor.orcidTakechi, Ryu [0000-0001-6359-3382]
curtin.contributor.orcidElnashar, Magdy [0000-0001-9936-3271]
curtin.contributor.orcidAl-Salami, Hani [0000-0003-0049-6969]
curtin.contributor.researcheridTakechi, Ryu [D-3692-2012]
curtin.contributor.researcheridAl-Salami, Hani [D-2509-2011]
curtin.identifier.article-numberARTN e0214984
dcterms.source.eissn1932-6203
curtin.contributor.scopusauthoridMooranian, Armin [55925814000]
curtin.contributor.scopusauthoridTakechi, Ryu [24173759200]
curtin.contributor.scopusauthoridElnashar, Magdy [6507505187]
curtin.contributor.scopusauthoridAl-Salami, Hani [24330693200]


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