The Cost-Utility of Magnetic Resonance Imaging for Breast Cancer in BRCA1 Mutation Carriers Aged 30–49
MetadataShow full item record
Recent evidence has investigated the costeffectiveness of magnetic resonance imaging (MRI) in younger women with a BRCA1 mutation. However, this evidence has not been contrasted with existing cost-effectiveness standards to determine whether screening is appropriate, given limited societal resources. We constructed a Markov model investigating surveillance tools (mammography, MRI, both in parallel) under a National Health Service (NHS) perspective. The key benefit of MRI is that increased sensitivity leads to early detection, and improved prognosis. For a 30- to 39-year-old cohort, the cost per quality-adjusted life year (QALY) of mammography relative to no screening was £5,200. The addition of MRI to this costs £13,486 per QALY. For a 40- to 49-year-old cohort, the corresponding values were £2,913 and £7,781. Probabilistic sensitivity analysis supported the cost-effectiveness of the parallel approach of mammography and MRI. It is necessary to extend this analysis beyond BRCA1 carriers within this age group, and also to other age groups.
Showing items related by title, author, creator and subject.
Treatment-focused DNA testing for newly diagnosed breast cancer patients: some implications for clinical practiceLobb, Elizabeth; Barlow-Stewart, K.; Suthers, G.; Hallowell, N. (2010)There is accumulating evidence that women with breast cancer due to a familial BRCA1 or BRCA2 mutation benefit from specific surgical and chemotherapeutic treatment strategies. However, the rapid identification of such ...
European radiographers’ challenges from mammography education and clinical practice – an integrative reviewMetsälä, E.; Meystre, N.; Jorge, J.; Henner, A.; Kukkes, T.; Sá dos Reis, Claudia (2017)Objectives: This study aims to identify European radiographers’ challenges in clinical performance in mammography and the main areas of mammography that require more and better training. Methods: An extensive search was ...
Carroll, P.; Nolan, C.; Clarke, R.; Farrell, M.; Gleeson, N.; Boyle, Terry; Dunne, B.; Daly, P.; John Kennedy, M.; Connolly, E. (2011)Little information is available regarding the management of BRCA-related breast cancer in Ireland. A cancer genetics programme was initiated in 1992 at our institution to provide counselling and expert management for those ...