The Cost-Utility of Magnetic Resonance Imaging for Breast Cancer in BRCA1 Mutation Carriers Aged 30–49
dc.contributor.author | Norman, Richard | |
dc.contributor.author | Evans, D. | |
dc.contributor.author | Easton, D. | |
dc.contributor.author | Young, K. | |
dc.date.accessioned | 2017-01-30T11:05:33Z | |
dc.date.available | 2017-01-30T11:05:33Z | |
dc.date.created | 2015-09-29T02:03:56Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Norman, R. and Evans, D. and Easton, D. and Young, K. 2007. The Cost-Utility of Magnetic Resonance Imaging for Breast Cancer in BRCA1 Mutation Carriers Aged 30–49. The European Journal of Health Economics. 8: pp. 137-144. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/8246 | |
dc.identifier.doi | 10.1007/s10198-007-0042-9 | |
dc.description.abstract |
Recent evidence has investigated the costeffectiveness of magnetic resonance imaging (MRI) in younger women with a BRCA1 mutation. However, this evidence has not been contrasted with existing cost-effectiveness standards to determine whether screening is appropriate, given limited societal resources. We constructed a Markov model investigating surveillance tools (mammography, MRI, both in parallel) under a National Health Service (NHS) perspective. The key benefit of MRI is that increased sensitivity leads to early detection, and improved prognosis. For a 30- to 39-year-old cohort, the cost per quality-adjusted life year (QALY) of mammography relative to no screening was £5,200. The addition of MRI to this costs £13,486 per QALY. For a 40- to 49-year-old cohort, the corresponding values were £2,913 and £7,781. Probabilistic sensitivity analysis supported the cost-effectiveness of the parallel approach of mammography and MRI. It is necessary to extend this analysis beyond BRCA1 carriers within this age group, and also to other age groups. | |
dc.publisher | Springer | |
dc.relation.uri | http://www.springer.com/economics/policy/journal/10198 | |
dc.subject | Cost-utility | |
dc.subject | Mammography | |
dc.subject | MRI | |
dc.subject | Surveillance | |
dc.subject | BRCA1 | |
dc.title | The Cost-Utility of Magnetic Resonance Imaging for Breast Cancer in BRCA1 Mutation Carriers Aged 30–49 | |
dc.type | Journal Article | |
dcterms.source.volume | 8 | |
dcterms.source.startPage | 137 | |
dcterms.source.endPage | 144 | |
dcterms.source.issn | 1618-7598 | |
dcterms.source.title | The European Journal of Health Economics | |
curtin.accessStatus | Fulltext not available |