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dc.contributor.authorNorman, Richard
dc.contributor.authorEvans, D.
dc.contributor.authorEaston, D.
dc.contributor.authorYoung, K.
dc.date.accessioned2017-01-30T11:05:33Z
dc.date.available2017-01-30T11:05:33Z
dc.date.created2015-09-29T02:03:56Z
dc.date.issued2007
dc.identifier.citationNorman, R. and Evans, D. and Easton, D. and Young, K. 2007. The Cost-Utility of Magnetic Resonance Imaging for Breast Cancer in BRCA1 Mutation Carriers Aged 30–49. The European Journal of Health Economics. 8: pp. 137-144.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/8246
dc.identifier.doi10.1007/s10198-007-0042-9
dc.description.abstract

Recent evidence has investigated the costeffectiveness of magnetic resonance imaging (MRI) in younger women with a BRCA1 mutation. However, this evidence has not been contrasted with existing cost-effectiveness standards to determine whether screening is appropriate, given limited societal resources. We constructed a Markov model investigating surveillance tools (mammography, MRI, both in parallel) under a National Health Service (NHS) perspective. The key benefit of MRI is that increased sensitivity leads to early detection, and improved prognosis. For a 30- to 39-year-old cohort, the cost per quality-adjusted life year (QALY) of mammography relative to no screening was £5,200. The addition of MRI to this costs £13,486 per QALY. For a 40- to 49-year-old cohort, the corresponding values were £2,913 and £7,781. Probabilistic sensitivity analysis supported the cost-effectiveness of the parallel approach of mammography and MRI. It is necessary to extend this analysis beyond BRCA1 carriers within this age group, and also to other age groups.

dc.publisherSpringer
dc.relation.urihttp://www.springer.com/economics/policy/journal/10198
dc.subjectCost-utility
dc.subjectMammography
dc.subjectMRI
dc.subjectSurveillance
dc.subjectBRCA1
dc.titleThe Cost-Utility of Magnetic Resonance Imaging for Breast Cancer in BRCA1 Mutation Carriers Aged 30–49
dc.typeJournal Article
dcterms.source.volume8
dcterms.source.startPage137
dcterms.source.endPage144
dcterms.source.issn1618-7598
dcterms.source.titleThe European Journal of Health Economics
curtin.accessStatusFulltext not available


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