Multiscale characterisation of Achilles tendons during mechanical loading

Abstract

Although mechanical loading correlate to multi-hierarchical changes, the multiscale response during tendon damage remains not yet fully understood. Therefore, this thesis assessed the multiscale structure-function mechanisms in response to different levels and durations of strains in GAG and un/depleted Achilles tendons. At the nano/macroscales, increased levels and durations of strains resulted in increased changes in form and function. This thesis identifies a variety of multiscale properties that may contribute to the understanding of the mechanism of tendon pathology.