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    Trimethylamine N-oxide (TMAO): a new attractive target to decrease cardiovascular risk.

    Access Status
    Fulltext not available
    Authors
    Swanepoel, Ione
    Roberts, April
    Brauns, Chelsea
    Chaliha, Devahuti
    Papa, Veronica
    Palmer, Raymond D
    Vaccarezza, Mauro
    Date
    2021
    Type
    Journal Article
    
    Metadata
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    Citation
    Swanepoel, I. and Roberts, A. and Brauns, C. and Chaliha, D.R. and Papa, V. and Palmer, R.D. and Vaccarezza, M. 2021. Trimethylamine N-oxide (TMAO): a new attractive target to decrease cardiovascular risk. Postgraduate Medical Journal.
    Source Title
    Postgraduate Medical Journal
    DOI
    10.1136/postgradmedj-2021-139839
    ISSN
    0032-5473
    Faculty
    Faculty of Health Sciences
    School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/83145
    Collection
    • Curtin Research Publications
    Abstract

    Cardiovascular disease (CVD) is one of the greatest disease burdens and takes the lives of many each year. There are many risk factors both modifiable and non-modifiable which contribute to the onset and progression of the disease. Trimethylamine N-oxide (TMAO) in recent years has been found to have a correlation with CVD onset. Those with increased levels of the metabolite have a markedly increased risk of future development of cardiometabolic disorders.This literature review aimed to critique past studies undertaken to find a consensus of the significance of the interrelationship between TMAO and cardiovascular risk. A definite link between TMAO levels and a CVD outcome was found. The majority of the literature stated the relationship with evidence; however, there is still some uncertainty as to why and how the correlation occurs. Further study needs to be done to further dissect and understand the relationship between TMAO and CVD risk.

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