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    Respiratory viral infections in Western Australians with cystic fibrosis

    Access Status
    Fulltext not available
    Authors
    Brestovac, Brian
    Lawrence, Charleigh
    Speers, D.J.
    Sammels, L.M.
    Mulrennan, S.
    Date
    2020
    Type
    Journal Article
    
    Metadata
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    Citation
    Brestovac, B. and Lawrence, C. and Speers, D.J. and Sammels, L.M. and Mulrennan, S. 2020. Respiratory viral infections in Western Australians with cystic fibrosis. Respiratory Medicine. 161: Article No. 105854.
    Source Title
    Respiratory Medicine
    DOI
    10.1016/j.rmed.2019.105854
    ISSN
    0954-6111
    Faculty
    Faculty of Health Sciences
    School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/84127
    Collection
    • Curtin Research Publications
    Abstract

    Background: Viral respiratory infections (VRI) in people living with Cystic fibrosis (CF) is less well understood than respiratory bacterial infections, particularly adults with CF and few studies have compared children with adults. This study evaluated the frequency of respiratory viruses in patients with cystic fibrosis (CF) in Western Australia (WA). We determined the VRI in CF and compared them with non-CF patients. Further, we compared CF patients that were hospitalised with those that were not.

    Patients/methods: Nucleic acid from sputum of 157 CF and 348 non-CF patients was analysed for influenzavirus A (Flu A) and B, (Flu B), respiratory syncytial virus (RSV), human metapneumovirus (hMPV), human rhinovirus (RV), and parainfluenza viruses (PIV 1-3) by RT-PCR, during the 2016 winter respiratory season.

    Results: No significant difference in the frequency of respiratory virus detection between CF and non-CF patients was found. RV was the most frequently detected virus in CF patients, and in hospitalised CF. RSV and hMPV were found less frequently in CF patients and RSV was not found in any hospitalised CF patient. A trend for fewer influenzavirus detections in adult CF patients was observed, however the trend was opposite for paediatric patients. RV and Flu A were the most common viruses detected in hospitalised CF patients.

    Conclusion: There was no significant difference in VRI between CF and non-CF patients. RV and influenza A were most commonly found in hospitalised CF patients, suggesting that infection with these viruses may contribute to hospitalisation for CF respiratory exacerbations.

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