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    Diagnostic value of multislice computed tomography angiography in coronary artery disease: A meta-analysis

    20284_20284.pdf (243.2Kb)
    Access Status
    Open access
    Authors
    Sun, Zhonghua
    Jiang, W.
    Date
    2006
    Type
    Journal Article
    
    Metadata
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    Citation
    Sun, Zhonghua and Jiang, Wen. 2006. Diagnostic value of multislice computed tomography angiography in coronary artery disease: A meta-analysis. European Journal of Radiology. 60 (2): 279-286.
    Source Title
    European Journal of Radiology
    DOI
    10.1016/j.ejrad.2006.06.009
    Faculty
    Department of Medical Imaging Science
    Division of Engineering, Science and Computing
    Faculty of Science
    Remarks

    Copyright 2006 Elsevier Ireland Ltd All rights reserved.

    NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Radiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in European Journal of Radiology, Volume 60, Issue 2, November 2006, Pages 279–286, http://dx.doi.org/10.1016/j.ejrad.2006.06.009,

    URI
    http://hdl.handle.net/20.500.11937/8453
    Collection
    • Curtin Research Publications
    Abstract

    Purpose: To perform a meta-analysis of the diagnostic value of multislice CT (MSCT) angiography in the detection of coronary artery disease (CAD) when compared to conventional coronary angiography.Materials and Methods: A search of PubMed and MEDLINE databases for English literature was performed. Only studies with at least 10 patients comparing MSCT angiography with conventional coronary angiography in the detection of CAD were included. Diagnostic value of MSCT angiography compared to coronary angiography was compared and analyzed at segment-, vessel- and patient-based assessment.Results: 47 studies (67 comparisons) met the criteria and were included in our study. Pooled overall sensitivity, specificity and 95% confidence interval for MSCT angiography in the detection of CAD were 83% (79%, 89%), 93% (91%, 96%) at segment-based analysis; 90% (87%, 94%), 87% (80%, 93%) at vessel-based analysis; and 91% (88%, 95%), 86% (81%, 92%) at patient-based analysis, respectively. Diagnostic accuracy of MSCT angiography in evaluating assessable segments was significantly improved with 64-slice scanners when compared to that with 4- and 16-slice scanners (p<0.05).Conclusion: Our meta-analysis showed that MSCT angiography has potential diagnostic accuracy in the detection of CAD. Diagnostic performance of MSCT angiography has been significantly improved with the latest 64-slice CT, with resultant high qualitative and quantitative diagnostic accuracy. 16-slice CT was limited in spatial resolution which makes it difficult to perform quantitative assessment of coronary artery stenoses.

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