Maternal immune activation as a risk factor for psychiatric illness in the context of the SARS-CoV-2 pandemic
MetadataShow full item record
Inflammation, due to infectious pathogens or other non-infectious stimuli, during pregnancy is associated with elevated risk for neurodevelopmental disorders such as schizophrenia and autism in the offspring. Although historically identified through retrospective epidemiologic studies, the relationship between maternal immune activation and offspring neurodevelopmental disease risk is now well established because of clinical studies which utilized prospective birth cohorts, serologically confirmed infection records, and subsequent long-term offspring follow-up. These efforts have been corroborated by preclinical research which demonstrates anatomical, biochemical, and behavioural alterations that resemble the clinical features of psychiatric illnesses. Intervention studies further demonstrate causal roles of inflammatory mediators, such as cytokines, in these long-lasting changes in behaviour and brain. This review summarizes a selection of maternal immune activation literature that explores the relationship between these inflammatory mediators and the neuropsychiatric-like effects later observed in the offspring. This literature is presented alongside emerging information regarding SARS-CoV-2 infection in pregnancy, with discussion of how these data may inform future research regarding the effects of the present coronavirus pandemic on emerging birth cohorts.
Showing items related by title, author, creator and subject.
Chih, Hui Jun ; Chan, Arlene; Lomma, Chris; Reid, Christopher (2019)Background: Cancer diagnosis impacts not only on the patients but their family. Impact of patients’ cancer stage on psychosocial distress or needs in their offspring has not been extensively studied. Aim: To assess incidence ...
Association of pre- and post-natal parental smoking with offspring body mass index: An 8-year follow-up of a birth cohortFlorath, Ines; Kohler, M.; Weck, M.; Brandt, S.; Rothenbacher, D.; Schöttker, B.; Moß, A.; Gottmann, P.; Wabitsch, M.; Brenner, H. (2014)© 2013 The Authors. Pediatric Obesity © 2013 International Association for the Study of Obesity. Summary What is already known about this subject Maternal smoking during pregnancy is associated with offspring overweight, ...
Maternal alcohol consumption during pregnancy and its association with offspring renal function at 30 years: observation from a birth cohort study.Das, S.; McIntyre, H.; Alati, Rosa; Al Mamun, A. (2017)AIM: Prenatal exposure to alcohol has adverse ramifications on foetal development resulting in developmental abnormalities and major congenital anomalies. Experimental studies have documented effects on kidney structure ...