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dc.contributor.authorLipton, Anuj Nishanth
dc.contributor.authorFathima, A.
dc.contributor.authorVincent, S.
dc.date.accessioned2021-08-06T01:17:19Z
dc.date.available2021-08-06T01:17:19Z
dc.date.issued2021
dc.identifier.citationLipton, A.N. and Fathima, A. and Vincent, S. 2021. In-vitro Evaluation of Chitosan - Hydroxyapatite Nanocomposite Scaffolds as Bone Substitutes with Antibiofilm Properties. Journal of Pure and Applied Microbiology (JPAM). 15 (3): pp. 1455-1471
dc.identifier.urihttp://hdl.handle.net/20.500.11937/85012
dc.identifier.doi10.22207/JPAM.15.3.39
dc.description.abstract

An opaque, white chitosan/ Hydroxyapatite nanocomposite was prepared by a simple blend method. Morphology, pore size and dispersion of nano-hydroxyapatite in chitosan matrix were visualized using SEM images. The FTIR and SEM with EDX analysis confirmed the bony apatite layer was formed on the outside of the composite. Porosity measurements and water uptake studies of the nanocomposite were evaluated which revealed the maximum porosity of 80% to 92% in the chitosan: hydroxyapatite nanocomposite at the ratio of 20:80. The results also showed that water absorption ability was inversely proportional to the hydroxyapatite present in the nanocomposite. The porosity of prepared nanocomposite was corresponding to the cancellous bone porosity of 50% to 90% suggesting possible applications in bone transplantation. The nanocomposite exhibited antibacterial activity towards the tested Gram-negative and Gram-positive species of bacteria and reduced the bacterial adhesion in biofilm formation.

dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleIn-vitro Evaluation of Chitosan - Hydroxyapatite Nanocomposite Scaffolds as Bone Substitutes with Antibiofilm Properties
dc.typeJournal Article
dcterms.source.titleJournal of Pure and Applied Microbiology (JPAM)
dc.date.updated2021-08-06T01:17:19Z
curtin.departmentCurtin International
curtin.accessStatusOpen access
curtin.facultyCurtin International
curtin.contributor.orcidLipton, Anuj Nishanth [0000-0001-5352-8755]


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