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    Investigating the role of inflammatory and neuronal repair genes in the neurological sequelae of HIV infection

    Gaff JA 2021.pdf (26.23Mb)
    Access Status
    Open access
    Authors
    Gaff, Jessica Anne
    Date
    2021
    Supervisor
    Patricia Price
    Type
    Thesis
    Award
    PhD
    
    Metadata
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    Faculty
    Health Sciences
    School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/86954
    Collection
    • Curtin Theses
    Abstract

    This thesis investigates factors that influence whether an HIV patient experiences sensory neuropathy or neurocognitive decline. I studied patients treated in Indonesia and South Africa. Genotypes that affect inflammation and neuronal repair influenced susceptibility to both neurological conditions. I used skin biopsies from Indonesian patients to show that proteins encoded by these genes are expressed by inflammatory cells around nerves damaged by neuropathy. This thesis identifies individuals at risk and provides insight into pathogenic mechanisms.

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