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dc.contributor.authorGaff, Jessica Anne
dc.contributor.supervisorPatricia Priceen_US
dc.date.accessioned2021-12-16T00:58:17Z
dc.date.available2021-12-16T00:58:17Z
dc.date.issued2021en_US
dc.identifier.urihttp://hdl.handle.net/20.500.11937/86954
dc.description.abstract

This thesis investigates factors that influence whether an HIV patient experiences sensory neuropathy or neurocognitive decline. I studied patients treated in Indonesia and South Africa. Genotypes that affect inflammation and neuronal repair influenced susceptibility to both neurological conditions. I used skin biopsies from Indonesian patients to show that proteins encoded by these genes are expressed by inflammatory cells around nerves damaged by neuropathy. This thesis identifies individuals at risk and provides insight into pathogenic mechanisms.

en_US
dc.publisherCurtin Universityen_US
dc.titleInvestigating the role of inflammatory and neuronal repair genes in the neurological sequelae of HIV infectionen_US
dc.typeThesisen_US
dcterms.educationLevelPhDen_US
curtin.departmentCurtin Medical Schoolen_US
curtin.accessStatusFulltext not availableen_US
curtin.facultyHealth Sciencesen_US
curtin.contributor.orcidGaff, Jessica Anne [0000-0002-4919-5078]en_US
dc.date.embargoEnd2023-12-14


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