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dc.contributor.authorChaliha, Devahuti
dc.contributor.authorVaccarezza, Mauro
dc.contributor.authorLam, Virginie
dc.contributor.authorTakechi, Ryu
dc.contributor.authorMamo, John
dc.identifier.citationChaliha, D. and Vaccarezza, M. and Lam, V. and Takechi, R. and Mamo, J.C. 2021. Attenuation of chronic tension headache frequency and severity with daily l-arginine and aged garlic extract dietary supplementation. European Journal of Clinical Nutrition.

A 74-year-old female subject with suboptimal management of episodic tension headache was treated with a daily dose of 1.5 g l-arginine and 1.2 g aged garlic extract (AGE). The aim of the intervention was to promote vasodilation of parenchymal cerebral blood vessels. Within 6 weeks of commencing treatment, her self-reported symptoms improved markedly and were sustained at 2 years following commencement. We propose that the putative beneficial effect of l-arginine and AGE in this patient is because of the well-established systemic vasodilatory effects of l-arginine and aged garlic extract. On the hypothesis that migraine is precipitated by cerebral microvascular constriction, we recommend a double-blind randomised controlled trial to clinically test this hypothesis in migraine patients.

dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectNutrition & Dietetics
dc.titleAttenuation of chronic tension headache frequency and severity with daily l-arginine and aged garlic extract dietary supplementation
dc.typeJournal Article
dcterms.source.titleEuropean Journal of Clinical Nutrition
curtin.departmentCurtin Medical School
curtin.departmentCurtin School of Population Health
curtin.departmentCurtin Health Innovation Research Institute(CHIRI)
curtin.accessStatusFulltext not available
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidLam, Virginie [0000-0001-8463-645X]
curtin.contributor.orcidVaccarezza, Mauro [0000-0003-3060-318X]
curtin.contributor.orcidTakechi, Ryu [0000-0001-6359-3382]
curtin.contributor.orcidMamo, John [0000-0002-5741-7849]
curtin.contributor.researcheridTakechi, Ryu [D-3692-2012]
curtin.contributor.scopusauthoridLam, Virginie [36096751600]
curtin.contributor.scopusauthoridVaccarezza, Mauro [6701350504]
curtin.contributor.scopusauthoridTakechi, Ryu [24173759200]
curtin.contributor.scopusauthoridMamo, John [7006456735]

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