Ergometrine stability in postpartum haemorrhage kits: Does temperature and light matter?
|dc.identifier.citation||Donnan, F. and Senarathna, S.M.D.K.G. and Ware, B. and Rawlins, M.D.M. and Dontham, C. and Chuang, V.T.G. and Batty, K.T. 2020. Ergometrine stability in postpartum haemorrhage kits: Does temperature and light matter? Australian and New Zealand Journal of Obstetrics and Gynaecology. 60 (3): pp. 344-349.|
Background: Postpartum haemorrhage (PPH) kits containing uterotonics are used on obstetric units for the timely management of PPH. Visible discolouration of ergometrine and ergometrine-oxytocin injections was observed in PPH kits stored in medical refrigerators on the obstetric unit at our hospital. Aim: To investigate the stability of ergometrine and ergometrine-oxytocin injections in PPH kits under simulated clinical storage conditions and to determine the potency of ampoules quarantined from PPH kits on our obstetric unit. Material and methods: Ergometrine and ergometrine-oxytocin injection ampoules were stored exposed to and protected from light at 4°C and room temperature (25°C) for up to three months, and assayed by high-performance liquid chromatography. Stability was based on the time for the ergometrine or oxytocin concentration to fall to 90% of the original concentration (t90). The potency of quarantined discoloured ampoules also was determined. Results: Ergometrine was stable at both temperatures for >6 months, when stored protected from light in simulated clinical conditions. When exposed to light, ergometrine was stable for approximately 4 days at 25°C and 10 days at 4°C. Discoloured ergometrine and ergometrine-oxytocin injection ampoules were found to be <90% of the nominal concentration. Conclusion: Stability of ergometrine in PPH kits is largely unaffected by temperature fluctuations (at 4°C and 25°C) over 6 months when protected from light. Ergometrine and ergometrine-oxytocin ampoules should be inspected prior to use and any discoloured ampoules discarded.
|dc.subject||Science & Technology|
|dc.subject||Life Sciences & Biomedicine|
|dc.subject||Obstetrics & Gynecology|
|dc.title||Ergometrine stability in postpartum haemorrhage kits: Does temperature and light matter?|
|dcterms.source.title||Australian and New Zealand Journal of Obstetrics and Gynaecology|
|curtin.department||Curtin Medical School|
|curtin.accessStatus||Fulltext not available|
|curtin.faculty||Faculty of Health Sciences|
|curtin.contributor.orcid||Chuang, Victor [0000-0002-2141-630X]|
|curtin.contributor.orcid||Batty, Kevin [0000-0003-3850-1778]|
|curtin.contributor.researcherid||Chuang, Victor [A-3644-2011]|
|curtin.contributor.scopusauthorid||Chuang, Victor |
|curtin.contributor.scopusauthorid||Batty, Kevin |
Files in this item
There are no files associated with this item.