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    Fuel feedstock determines biodiesel exhaust toxicity in a human airway epithelial cell exposure model

    Access Status
    Open access via publisher
    Authors
    Landwehr, Katherine R.
    Hillas, J.
    Mead-Hunter, Ryan
    Brooks, P.
    King, Andrew
    O'Leary, R.A.
    Kicic, Anthony
    Mullins, Ben
    Larcombe, Alexander
    Date
    2021
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Landwehr, K.R. and Hillas, J. and Mead-Hunter, R. and Brooks, P. and King, A. and O'Leary, R.A. and Kicic, A. et al. 2021. Fuel feedstock determines biodiesel exhaust toxicity in a human airway epithelial cell exposure model. Journal of Hazardous Materials. 420: ARTN 126637.
    Source Title
    Journal of Hazardous Materials
    DOI
    10.1016/j.jhazmat.2021.126637
    Additional URLs
    https://www.sciencedirect.com/science/article/am/pii/S0304389421016022
    ISSN
    0304-3894
    Faculty
    Faculty of Health Sciences
    School
    Curtin School of Population Health
    Funding and Sponsorship
    http://purl.org/au-research/grants/arc/DP170104346
    URI
    http://hdl.handle.net/20.500.11937/90019
    Collection
    • Curtin Research Publications
    Abstract

    Background: Biodiesel is promoted as a sustainable replacement for commercial diesel. Biodiesel fuel and exhaust properties change depending on the base feedstock oil/fat used during creation. The aims of this study were, for the first time, to compare the exhaust exposure health impacts of a wide range of biodiesels made from different feedstocks and relate these effects with the corresponding exhaust characteristics. Method: Primary airway epithelial cells were exposed to diluted exhaust from an engine running on conventional diesel and biodiesel made from Soy, Canola, Waste Cooking Oil, Tallow, Palm and Cottonseed. Exhaust properties and cellular viability and mediator release were analysed post exposure. Results: The exhaust physico-chemistry of Tallow biodiesel was the most different to diesel as well as the most toxic, with exposure resulting in significantly decreased cellular viability (95.8 ± 6.5%) and increased release of several immune mediators including IL-6 (+223.11 ± 368.83 pg/mL) and IL-8 (+1516.17 ± 2908.79 pg/mL) above Air controls. In contrast Canola biodiesel was the least toxic with exposure only increasing TNF-α (4.91 ± 8.61). Conclusion: This study, which investigated the toxic effects for the largest range of biodiesels, shows that exposure to different exhausts results in a spectrum of toxic effects in vitro when combusted under identical conditions.

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    • Toxicity of different biodiesel exhausts in primary human airway epithelial cells grown at air-liquid interface
      Landwehr, K.R.; Hillas, J.; Mead-Hunter, Ryan ; King, A.; O'Leary, R.A.; Kicic, Anthony ; Mullins, Ben ; Larcombe, Alexander (2022)
      Biodiesel is created through the transesterification of fats/oils and its usage is increasing worldwide as global warming concerns increase. Biodiesel fuel properties change depending on the feedstock used to create it. ...
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      Landwehr, K.R.; Hillas, J.; Mead-Hunter, Ryan ; King, Andrew ; O'Leary, R.A.; Kicic, Anthony ; Mullins, Ben ; Larcombe, Alexander (2023)
      To address climate change concerns, and reduce the carbon footprint caused by fossil fuel use, it is likely that blend ratios of renewable biodiesel with commercial mineral diesel fuel will steadily increase, resulting ...
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      Landwehr, Katherine; Mead-Hunter, Ryan ; O'Leary, R.A.; Kicic, Anthony ; Mullins, Ben ; Larcombe, Alexander (2024)
      Background: Biodiesel, a renewable diesel fuel that can be created from almost any natural fat or oil, is promoted as a greener and healthier alternative to commercial mineral diesel without the supporting experimental ...
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