Incidence, Predictors and Outcomes of Major Bleeding in Patients Following Percutaneous Coronary Interventions in Australia
MetadataShow full item record
Background: Major bleeding is a serious complication of percutaneous coronary intervention (PCI). We set out to investigate the incidence of major bleeding and its impact on hospitalisation and long-term mortality. Method: We examined seven years of registry data encompassing 16,860 PCI procedures. Results: Between 2005 and 2011 major bleeding increased from 1.3% to 3.4%. In patients with ST elevated myocardial infarction (STEMI), the rate increased from 2.3% to 6.4%. The increase remained significant after adjusting for patient and procedural characteristics (OR=1.09/year, p=0.001). Bleeding risk was highest in patients presenting with out-of-hospital cardiac arrest and cardiogenic shock (CS). Women, STEMI patients, those aged over 70yrs or weighing <60 kg were at higher risk. Glycoprotein IIb/IIIa-inhibitor use more than doubled the risk of bleeding (OR=2.28, p=<0.001). Mortality rates at one year were 4.18% overall and 7.9% in STEMI. Bleeding was a strong predictor of mortality after adjusting for potential confounders (HR=2.92, 95% CI: 2.08, 4.09). Bleeding significantly increased length of stay (med four days vs seven days) and rehospitalisation at 12 months (OR=1.36, 95% CI: 1.08, 1.70). Conclusions: Major bleeding rates post-PCI appear to be increasing in Australia. Bleeding increases hospitalisation and is associated with poor clinical outcomes.
Showing items related by title, author, creator and subject.
Aubron, C.; Kandane-Rathnayake, R.; Andrianopoulos, N.; Westbrook, A.; Engelbrecht, S.; Ozolins, I.; Bailey, M.; Murray, L.; Cooper, D.; Wood, E.; McQuilten, Z.; Westbrook, A.; Pettilä, V.; Nichol, A.; Bailey, M.; Wood, E.; Syres, G.; Phillips, L.; Street, A.; French, C.; Murray, L.; Orford, N.; Santamaria, J.; Bellomo, R.; Nichol, A.; Street, A.; Vallance, S.; McArthur, C.; McGuiness, S.; Newby, L.; Simmonds, C.; Parke, R.; Buhr, H.; Bellomo, R.; Goldsmith, D.; O'Sullivan, K.; Mercer, I.; Gazzard, R.; Tauschke, C.; Hill, D.; Fletcher, J.; Boschert, C.; Koch, G.; Ernest, D.; Eliott, S.; Howe, B.; Hawker, F.; Ellem, K.; Duff, K.; Henderson, S.; Mehrtens, J.; Milliss, D.; Wong, H.; Arora, S.; O'Bree, B.; Shepherd, K.; Ihle, B.; Ho, S.; Ihle, B.; Graan, M.; Bernsten, A.; Ryan, E.; Botha, J.; Vuat, J.; Orford, N.; Kinmonth, A.; Fraser, M.; Richards, B.; Tallott, M.; Whitbread, R.; Freebairn, R.; Thomas, L.; Parr, M.; Micallef, S.; Deshpande, K.; Wood, J.; Williams, Teresa; Tai, J.; Boase, A.; Arora, S.; Galt, P.; King, B.; Price, R.; Tomlinson, J.; Cole, L.; Seppelt, I.; Weisbrodt, L.; Gresham, R.; Nikas, M.; Laing, J.; Bell, J.; McHugh, G.; Hancock, D.; Kirkham, S.; Shehabi, Y.; Campbell, M. (2018)Background and objectives: The timing of blood administration in critically ill patients is first driven by patients' needs. This study aimed to define the epidemiology and significance of overnight transfusion in critically ...
Antithrombotic regimens in patients with percutaneous coronary intervention whom an anticoagulant is indicated: A systematic review and network meta -analysisBunmark, W.; Jinatongthai, P.; Vathesatogkit, P.; Thakkinstian, A.; Reid, Christopher; Wongcharoen, W.; Chaiyakunapruk, N.; Nathisuwan, S. (2018)Background: Patients undergoing percutaneous coronary intervention (PCI) who require anticoagulant therapy are at increased risk of bleeding. The optimal regimen for these patients is uncertain. This study aimed to compare ...
Hemoglobin and Change in Hemoglobin Status Predict Mortality, Cardiovascular Events, and Bleeding in Stable Coronary Artery DiseaseKalra, P.; Greenlaw, N.; Ferrari, R.; Ford, I.; Tardif, J.; Tendera, M.; Reid, Christopher; Danchin, N.; Stepinska, J.; Steg, P.; Fox, K. (2017)Background: Anemia is a predictor of adverse outcomes in acute myocardial infarction. We studied the relationship of hemoglobin, or its change over time, and outcomes in patients with stable coronary artery disease. ...