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dc.contributor.authorWlodarczyk, J.
dc.contributor.authorAjani, A.
dc.contributor.authorKemp, D.
dc.contributor.authorAndrianopoulos, N.
dc.contributor.authorBrennan, A.
dc.contributor.authorDuffy, S.
dc.contributor.authorClark, D.
dc.contributor.authorReid, Christopher
dc.identifier.citationWlodarczyk, J. and Ajani, A. and Kemp, D. and Andrianopoulos, N. and Brennan, A. and Duffy, S. and Clark, D. et al. 2015. Incidence, Predictors and Outcomes of Major Bleeding in Patients Following Percutaneous Coronary Interventions in Australia. Heart Lung and Circulation. 25 (2): pp. 107-117.

Background: Major bleeding is a serious complication of percutaneous coronary intervention (PCI). We set out to investigate the incidence of major bleeding and its impact on hospitalisation and long-term mortality. Method: We examined seven years of registry data encompassing 16,860 PCI procedures. Results: Between 2005 and 2011 major bleeding increased from 1.3% to 3.4%. In patients with ST elevated myocardial infarction (STEMI), the rate increased from 2.3% to 6.4%. The increase remained significant after adjusting for patient and procedural characteristics (OR=1.09/year, p=0.001). Bleeding risk was highest in patients presenting with out-of-hospital cardiac arrest and cardiogenic shock (CS). Women, STEMI patients, those aged over 70yrs or weighing <60 kg were at higher risk. Glycoprotein IIb/IIIa-inhibitor use more than doubled the risk of bleeding (OR=2.28, p=<0.001). Mortality rates at one year were 4.18% overall and 7.9% in STEMI. Bleeding was a strong predictor of mortality after adjusting for potential confounders (HR=2.92, 95% CI: 2.08, 4.09). Bleeding significantly increased length of stay (med four days vs seven days) and rehospitalisation at 12 months (OR=1.36, 95% CI: 1.08, 1.70). Conclusions: Major bleeding rates post-PCI appear to be increasing in Australia. Bleeding increases hospitalisation and is associated with poor clinical outcomes.

dc.publisherElsevier Ltd
dc.titleIncidence, Predictors and Outcomes of Major Bleeding in Patients Following Percutaneous Coronary Interventions in Australia
dc.typeJournal Article
dcterms.source.titleHeart Lung and Circulation
curtin.departmentDepartment of Health Policy and Management
curtin.accessStatusFulltext not available

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