Show simple item record

dc.contributor.authorHenry, C.J.
dc.contributor.authorSemova, G.
dc.contributor.authorBarnes, E.
dc.contributor.authorCotter, I.
dc.contributor.authorDevers, T.
dc.contributor.authorRafaee, A.
dc.contributor.authorSlavescu, A.
dc.contributor.authorCathain, N.O.
dc.contributor.authorMcCollum, D.
dc.contributor.authorRoche, E.
dc.contributor.authorMockler, D.
dc.contributor.authorAllen, J.
dc.contributor.authorMeehan, J.
dc.contributor.authorKlingenberg, C.
dc.contributor.authorLatour, Jos
dc.contributor.authorvan den Hoogen, A.
dc.contributor.authorStrunk, T.
dc.contributor.authorGiannoni, E.
dc.contributor.authorSchlapbach, L.J.
dc.contributor.authorDegtyareva, M.
dc.contributor.authorPlötz, F.B.
dc.contributor.authorde Boode, W.P.
dc.contributor.authorNaver, L.
dc.contributor.authorWynn, J.L.
dc.contributor.authorKüster, H.
dc.contributor.authorJanota, J.
dc.contributor.authorKeij, F.M.
dc.contributor.authorReiss, I.K.M.
dc.contributor.authorBliss, J.M.
dc.contributor.authorPolin, R.
dc.contributor.authorKoenig, J.M.
dc.contributor.authorTurner, M.A.
dc.contributor.authorGale, C.
dc.contributor.authorMolloy, E.J.
dc.date.accessioned2023-12-26T06:41:39Z
dc.date.available2023-12-26T06:41:39Z
dc.date.issued2022
dc.identifier.citationHenry, C.J. and Semova, G. and Barnes, E. and Cotter, I. and Devers, T. and Rafaee, A. and Slavescu, A. et al. 2022. Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials. Pediatric Research. 91 (4): pp. 735-742.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/94048
dc.identifier.doi10.1038/s41390-021-01883-y
dc.description.abstract

Background: The lack of a consensus definition of neonatal sepsis and a core outcome set (COS) proves a substantial impediment to research that influences policy and practice relevant to key stakeholders, patients and parents. Methods: A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. In the included studies, the described outcomes were extracted in accordance with the provisions of the Core Outcome Measures in Effectiveness Trials (COMET) handbook and registered. Results: Among 884 abstracts identified, 90 randomised controlled trials (RCTs) were included in this review. Only 30 manuscripts explicitly stated the primary and/or secondary outcomes. A total of 88 distinct outcomes were recorded across all 90 studies included. These were then assigned to seven different domains in line with the taxonomy for classification proposed by the COMET initiative. The most frequently reported outcome was survival with 74% (n = 67) of the studies reporting an outcome within this domain. Conclusions: This systematic review constitutes one of the initial phases in the protocol for developing a COS in neonatal sepsis. The paucity of standardised outcome reporting in neonatal sepsis hinders comparison and synthesis of data. The final phase will involve a Delphi Survey to generate a COS in neonatal sepsis by consensus recommendation. Impact: This systematic review identified a wide variation of outcomes reported among published RCTs on the management of neonatal sepsis.The paucity of standardised outcome reporting hinders comparison and synthesis of data and future meta-analyses with conclusive recommendations on the management of neonatal sepsis are unlikely.The final phase will involve a Delphi Survey to determine a COS by consensus recommendation with input from all relevant stakeholders.

dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleNeonatal sepsis: a systematic review of core outcomes from randomised clinical trials
dc.typeJournal Article
dcterms.source.volume91
dcterms.source.number4
dcterms.source.startPage735
dcterms.source.endPage742
dcterms.source.issn0031-3998
dcterms.source.titlePediatric Research
dc.date.updated2023-12-26T06:41:35Z
curtin.departmentCurtin School of Nursing
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidLatour, Jos [0000-0001-9677-8340] [0000-0002-8087-6461]
curtin.contributor.researcheridLatour, Jos [ABE-9521-2020]
dcterms.source.eissn1530-0447
curtin.contributor.scopusauthoridLatour, Jos [23019310400] [57218590755]
curtin.repositoryagreementV3


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/