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dc.contributor.authorGorman, S.
dc.contributor.authorBlack, Lucinda
dc.contributor.authorFeelisch, M.
dc.contributor.authorHart, P.
dc.contributor.authorWeller, R.
dc.identifier.citationGorman, S. and Black, L. and Feelisch, M. and Hart, P. and Weller, R. 2015. Can skin exposure to sunlight prevent liver inflammation?. Nutrients. 7 (5): pp. 3219-3239.

Liver inflammation contributes towards the pathology of non-alcoholic fatty liver disease (NAFLD). Here we discuss how skin exposure to sunlight may suppress liver inflammation and the severity of NAFLD. Following exposure to sunlight-derived ultraviolet radiation (UVR), the skin releases anti-inflammatory mediators such as vitamin D and nitric oxide. Animal modeling studies suggest that exposure to UVR can prevent the development of NAFLD. Association studies also support a negative link between circulating 25-hydroxyvitamin D and NAFLD incidence or severity. Clinical trials are in their infancy and are yet to demonstrate a clear beneficial effect of vitamin D supplementation. There are a number of potentially interdependent mechanisms whereby vitamin D could dampen liver inflammation, by inhibiting hepatocyte apoptosis and liver fibrosis, modulating the gut microbiome and through altered production and transport of bile acids. While there has been a focus on vitamin D, other mediators induced by sun exposure, such as nitric oxide may also play important roles in curtailing liver inflammation.

dc.publisherMDPI Publishing
dc.titleCan skin exposure to sunlight prevent liver inflammation?
dc.typeJournal Article

This open access article is distributed under the Creative Commons license

curtin.departmentSchool of Public Health
curtin.accessStatusOpen access

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