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    Polymorphism of sheep MHC Class IIb gene TAPASIN

    149839_149839.pdf (51.21Kb)
    Access Status
    Open access
    Authors
    Siva Subramaniam, N.
    Morgan, Eleanor
    Lee, C.
    Wetherall, John
    Groth, David
    Date
    2010
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Siva Subramaniam, N. and Morgan, E.F. and Lee, C.Y. and Wetherall, J.D. and Groth, D.M. 2010. Polymorphism of sheep MHC Class IIb gene TAPASIN. Veterinary Immunology and Immunopathology. 137 (1-2): pp. 176-180.
    Source Title
    Veterinary Immunology and Immunopathology
    DOI
    10.1016/j.vetimm.2010.04.018
    ISSN
    01652427
    Faculty
    Faculty of Health Sciences
    School of Biomedical Sciences
    Remarks

    The link to the journal’s home page is: http://www.elsevier.com/wps/find/journaldescription.cws_home/503319/description#description. Copyright © 2010 Elsevier B.V. All rights reserved

    URI
    http://hdl.handle.net/20.500.11937/9989
    Collection
    • Curtin Research Publications
    Abstract

    The Major Histocompatibility Complex (MHC) is one of the most gene dense regions in the genome and studies in several species have shown significant associations between the MHC and disease. The endoplasmic reticular glycoprotein, tapasin, is involved in the MHC class I antigen presentation pathway. Sheep TAPASIN is located in the class IIb region of the MHC. Sheep TAPASIN was subcloned from BAC and cosmid genomic clones and DNA sequenced. TAPASIN is 9549 bp in length and encodes a protein of 447 amino acids. The structure of sheep TAPASIN was similar to other mammals and consisted of eight exons with a distinctively larger intron between exon three and four. Sheep TAPASIN gene had high sequence identity with other mammalian TAPASINs. The TAPASIN gene sequence is conserved across many mammalian species and is possibly maintained through purifying selection with the average ratio of ds/dn of 3.9. Twenty-six SNPs in sheep TAPASIN were identified.

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