Polymorphism of sheep MHC Class IIb gene TAPASIN
dc.contributor.author | Siva Subramaniam, N. | |
dc.contributor.author | Morgan, Eleanor | |
dc.contributor.author | Lee, C. | |
dc.contributor.author | Wetherall, John | |
dc.contributor.author | Groth, David | |
dc.date.accessioned | 2017-01-30T11:16:12Z | |
dc.date.available | 2017-01-30T11:16:12Z | |
dc.date.created | 2010-12-09T20:02:58Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Siva Subramaniam, N. and Morgan, E.F. and Lee, C.Y. and Wetherall, J.D. and Groth, D.M. 2010. Polymorphism of sheep MHC Class IIb gene TAPASIN. Veterinary Immunology and Immunopathology. 137 (1-2): pp. 176-180. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/9989 | |
dc.identifier.doi | 10.1016/j.vetimm.2010.04.018 | |
dc.description.abstract |
The Major Histocompatibility Complex (MHC) is one of the most gene dense regions in the genome and studies in several species have shown significant associations between the MHC and disease. The endoplasmic reticular glycoprotein, tapasin, is involved in the MHC class I antigen presentation pathway. Sheep TAPASIN is located in the class IIb region of the MHC. Sheep TAPASIN was subcloned from BAC and cosmid genomic clones and DNA sequenced. TAPASIN is 9549 bp in length and encodes a protein of 447 amino acids. The structure of sheep TAPASIN was similar to other mammals and consisted of eight exons with a distinctively larger intron between exon three and four. Sheep TAPASIN gene had high sequence identity with other mammalian TAPASINs. The TAPASIN gene sequence is conserved across many mammalian species and is possibly maintained through purifying selection with the average ratio of ds/dn of 3.9. Twenty-six SNPs in sheep TAPASIN were identified. | |
dc.publisher | ELSEVIER | |
dc.subject | polymorphism | |
dc.subject | TAP-binding protein | |
dc.subject | SNP | |
dc.subject | TAPASIN | |
dc.subject | sheep | |
dc.subject | MHC | |
dc.title | Polymorphism of sheep MHC Class IIb gene TAPASIN | |
dc.type | Journal Article | |
dcterms.source.volume | xxx | |
dcterms.source.number | xx | |
dcterms.source.startPage | xxx | |
dcterms.source.endPage | xxx | |
dcterms.source.issn | 01652427 | |
dcterms.source.title | Veterinary Immunology and Immunopathology | |
curtin.note |
The link to the journal’s home page is: | |
curtin.accessStatus | Open access | |
curtin.faculty | Faculty of Health Sciences | |
curtin.faculty | School of Biomedical Sciences |