Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Serum mesothelin for early detection of asbestos-induced cancer malignant mesothelioma

    Access Status
    Open access via publisher
    Authors
    Creaney, J.
    Olsen, N.
    Brims, Fraser
    Dick, I.
    Musk, A.
    De Klerk, N.
    Skates, S.
    Robinson, B.
    Date
    2010
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Creaney, J. and Olsen, N. and Brims, F. and Dick, I. and Musk, A. and De Klerk, N. and Skates, S. et al. 2010. Serum mesothelin for early detection of asbestos-induced cancer malignant mesothelioma. Cancer Epidemiology Biomarkers and Prevention. 19 (9): pp. 2238-2246.
    Source Title
    Cancer Epidemiology Biomarkers and Prevention
    DOI
    10.1158/1055-9965.EPI-10-0346
    ISSN
    1055-9965
    School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/9994
    Collection
    • Curtin Research Publications
    Abstract

    Background: Malignant mesothelioma is an aggressive, almost uniformly fatal tumor, primarily caused by exposure to asbestos. Since the recent discovery that serum mesothelin is a sensitive and highly specific biomarker for mesothelioma, one of the key issues raised is whether mesothelin levels represent a useful screening test for asbestos-exposed at-risk individuals. In this study, soluble mesothelin was determined in sequential serum samples collected from asbestos-exposed individuals before the development of mesothelioma. Methods: Archival serum samples from 106 individuals who developed mesothelioma, 99 asbestosexposed individuals from the Wittenoom Cancer Surveillance Program, and 109 non-asbestos-exposed individuals from the Busselton Health Survey were identified. Serum mesothelin concentrations were determined using the MESOMARK assay. Results: Longitudinal mesothelin levels determined in healthy asbestos-exposed individuals over a period of 4 years were stable (Pearson's r = 0.96; P < 0.0001). There was no correlation between mesothelin concentration and cumulative asbestos exposure. Mesothelin concentrations were greater than the threshold value of 2.5 nmol/L in the penultimate serum sample before the diagnosis of mesothelioma in 17 of 106 people. Using an increase above the 95% confidence interval of the mean of a given individual's longitudinal mesothelin results, 33 of 82 individuals had increasing mesothelin levels before diagnosis. Conclusion: In a population with a high pretest probability of developing mesothelioma, the serum biomarker mesothelin is elevated in absolute terms in 15% and in relative terms in 40% of the group. Impact: Future studies examining a combination of biomarkers could improve sensitivity of screening. ©2010 AACR.

    Related items

    Showing items related by title, author, creator and subject.

    • A genome-wide association study for malignant mesothelioma risk
      Cadby, G.; Mukherjee, S.; Musk, A.; Reid, A.; Garlepp, Michael; Dick I.; Robinson, C.; Hui, J.; Fiorito, G.; Guarrera, S.; Beilby, J.; Melton, P.; Moses, E.; Ugolini, D.; Mirabelli, D.; Bonassi, S.; Magnani, C.; Dianzani, I.; Matullo, G.; Robinson, B.; Creaney, J.; Palmer, L. (2013)
      Malignant mesothelioma (MM) is a uniformly fatal tumour of mesothelial cells. MM is caused by exposure to asbestos however most individuals with documented asbestos exposure do not develop MM. Although MM appears to ...
    • Autoantibodies and cancer among asbestos-exposed cohorts in Western Australia
      Carey, Renee ; Pfau, J.C.; Fritzler, M.J.; Creaney, J.; de Klerk, N.; Musk, A. W. (Bill); Franklin, P.; Sodhi-Berry, N.; Brims, Fraser ; Reid, Alison (2021)
      Asbestos exposure is associated with many adverse health conditions including malignant mesothelioma and lung cancer as well as production of autoantibodies. Autoantibodies may serve as biomarkers for asbestos exposure ...
    • Statins do not alter the incidence of mesothelioma in asbestos exposed mice or humans
      Robinson, C.; Alfonso, Helman; Woo, S.; Walsh, A.; Olsen, N.; Musk, A.; Robinson, B.; Nowak, A.; Lake, R. (2014)
      Mesothelioma is principally caused by asbestos and may be preventable because there is a long latent period between exposure and disease development. The most at-risk are a relatively well-defined population who were ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.