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dc.contributor.authorCreaney, J.
dc.contributor.authorOlsen, N.
dc.contributor.authorBrims, Fraser
dc.contributor.authorDick, I.
dc.contributor.authorMusk, A.
dc.contributor.authorDe Klerk, N.
dc.contributor.authorSkates, S.
dc.contributor.authorRobinson, B.
dc.identifier.citationCreaney, J. and Olsen, N. and Brims, F. and Dick, I. and Musk, A. and De Klerk, N. and Skates, S. et al. 2010. Serum mesothelin for early detection of asbestos-induced cancer malignant mesothelioma. Cancer Epidemiology Biomarkers and Prevention. 19 (9): pp. 2238-2246.

Background: Malignant mesothelioma is an aggressive, almost uniformly fatal tumor, primarily caused by exposure to asbestos. Since the recent discovery that serum mesothelin is a sensitive and highly specific biomarker for mesothelioma, one of the key issues raised is whether mesothelin levels represent a useful screening test for asbestos-exposed at-risk individuals. In this study, soluble mesothelin was determined in sequential serum samples collected from asbestos-exposed individuals before the development of mesothelioma. Methods: Archival serum samples from 106 individuals who developed mesothelioma, 99 asbestosexposed individuals from the Wittenoom Cancer Surveillance Program, and 109 non-asbestos-exposed individuals from the Busselton Health Survey were identified. Serum mesothelin concentrations were determined using the MESOMARK assay. Results: Longitudinal mesothelin levels determined in healthy asbestos-exposed individuals over a period of 4 years were stable (Pearson's r = 0.96; P < 0.0001). There was no correlation between mesothelin concentration and cumulative asbestos exposure. Mesothelin concentrations were greater than the threshold value of 2.5 nmol/L in the penultimate serum sample before the diagnosis of mesothelioma in 17 of 106 people. Using an increase above the 95% confidence interval of the mean of a given individual's longitudinal mesothelin results, 33 of 82 individuals had increasing mesothelin levels before diagnosis. Conclusion: In a population with a high pretest probability of developing mesothelioma, the serum biomarker mesothelin is elevated in absolute terms in 15% and in relative terms in 40% of the group. Impact: Future studies examining a combination of biomarkers could improve sensitivity of screening. ©2010 AACR.

dc.publisherAmerican Association for Cancer Research Inc
dc.titleSerum mesothelin for early detection of asbestos-induced cancer malignant mesothelioma
dc.typeJournal Article
dcterms.source.titleCancer Epidemiology Biomarkers and Prevention
curtin.departmentCurtin Medical School
curtin.accessStatusOpen access via publisher

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