Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Depth-dependent refractive index of normal and early degenerated articular cartilage

    197307_108635_JBO_18_10_105003.pdf (1.305Mb)
    Access Status
    Open access
    Authors
    Wang, K.
    Wu, Jianping
    Kirk, Thomas
    Date
    2013
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Wang, Kuyu and Wu, Jianping and Kirk, Thomas. 2013. Depth-dependent refractive index of normal and early degenerated articular cartilage. Journal of Biomedical Optics. 18 (10): 105003 (8 pp.).
    Source Title
    Journal of Biomedical Optics
    DOI
    10.1117/1.JBO.18.10.105003
    ISSN
    1083-3668
    Remarks

    This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/ Please refer to the licence to obtain terms for any further reuse or distribution of this work.

    URI
    http://hdl.handle.net/20.500.11937/10969
    Collection
    • Curtin Research Publications
    Abstract

    The depth distributions of refractive index (RI) in normal and early degenerated articular cartilage (AC) were measured and correlated to the pathological statuses. Utilizing a confocal microscope, the depth distribution of RI was determined with an interval of 50µm from the articular surface and approximated as a smooth curve. The fluctuation of RI was quantified with a specially defined coefficient and the proteoglycan (PG) loss was quantified with histological images. The overall RI of the AC collected from the femoral condyles of mature sheep was 1.4444. Significant differences existed in the refractive indices of different cartilage samples or even in the different depths of the same sample. The RI of normal cartilage distributed as a regular ramp or arch curve with depth and peaked in the middle-deep zone. The cartilage samples detected with high PG losses were coupled with severe fluctuations of RI. The fluctuating level was increased with pathological progress. The coefficient of RI fluctuation can distinguish the normal cartilage from the initially degenerated one, which potentially provides an indicator to detect the pathological development of AC.

    Related items

    Showing items related by title, author, creator and subject.

    • Characterizing depth-dependent refractive index of articular cartilage subjected to mechanical wear or enzymic degeneration
      Wang, K.; Wu, Jian-Ping; Day, R.; Kirk, Brett; Hu, X. (2016)
      Utilizing a laser scanning confocal microscope system, the refractive indices of articular cartilage (AC) with mechanical or biochemical degenerations were characterized to investigate whether potential correlations exist ...
    • Utilizing confocal microscopy to measure refractive index of articular cartilage
      Wang, K.; Wu, Ping; Day, R.; Kirk, Thomas Brett (2012)
      This study proposes a method for measuring the refractive index of articular cartilage within a thin and small specimen slice. The cartilage specimen, with a thickness of about 50 μm, was put next to a thin film of immersion ...
    • Study of morphologic response of chondrocytes to uniaxial compression of articular cartilage
      Wu, Ping; Kirk, Brett; Milne, N.; Delaney, P. (2008)
      Osteoarthritis is synonymous to the functional disorder of articular cartilage. Mechanical tests of articular cartilage offer a way to understand the tissue’s functionality and osteoarthritis. During normal activities, ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.